Protein Alignment Dop1R1 and HTR1F

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_000857.1
• Gene: HTR1F / 3355
• HGNCID: 5292
• Length: 366
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 122/387 - (31%)
• Similarity: 184/387 - (47%)
• Gaps: 61/387 - (15%)

  Fly   100 FYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGN 164
            |.|.|.....||  .::...|      |.::|.:.||.|..::...|.||..||...|.|....|
Human     3 FLNSSDQNLTSE--ELLNRMP------SKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPAN 59

  Fly   165 LFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIH 229
            ..:.|||:.|..||.|||.|:.|..:...||.|...||.|::.|:.|.|.|||:|.||::|||..
Human    60 YLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRA 124

  Fly   230 IKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPI---SLGIHRPDQPLIFEDNGKKYPTCALDL 291
            |.|.:.|.|..|.:.|.|.|..:|:::.|:|..|:   ..|..|.|:.:|..|:
Human   125 ITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDH----------- 178

  Fly   292 TPTYAVVSSCIS----FYFPCVVMIGIYCRLY-----CYAQKHVKSI-------KAVTRPGEVAE 340
                 :||:..|    ||.|..:::.:|.::|     .|.::....|       :.:...||.:.
Human   179 -----IVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKST 238

  Fly   341 KQ---RY---KSIRRPKNQPKKF--KVRNLHT---HSSPYH------VSDHKAAVTVGVIMGVFL 388
            |.   .|   ||:..|.....|.  .||:|.:   |...:.      ..:.|||.|:|:|:|.|:
Human   239 KSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFV 303

  Fly   389 ICWVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            |||:|||...:....|..| |..:....|.||||.||..||:||:|||::|:.||::::..|
Human   304 ICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	112/348 (32%)
		TM helix 1	130..156	CDD:320193	9/25 (36%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	7/24 (29%)
		TM helix 5	292..321	CDD:320193	8/37 (22%)
		TM helix 6	371..401	CDD:320193	14/29 (48%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
HTR1F	NP_000857.1	7tmA_5-HT1F	24..359	CDD:320456	113/350 (32%)
		TM helix 1	25..51	CDD:320456	9/25 (36%)
		TM helix 2	58..84	CDD:320456	12/25 (48%)
		TM helix 3	96..126	CDD:320456	15/29 (52%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	7/21 (33%)
		TM helix 5	178..207	CDD:320456	8/44 (18%)
		TM helix 6	286..316	CDD:320456	14/29 (48%)
		TM helix 7	326..351	CDD:320456	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347		2/3 (67%)