Protein Alignment Dop1R1 and HTR1B

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 110/378 - (29%)
• Similarity: 178/378 - (47%)
• Gaps: 58/378 - (15%)

  Fly   108 NASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAI 172
            |.|..|.|.   .:.:||...|::.:.|:::...:...|..|...:|..|.|....|..:||||:
Human    32 NCSAKDYIY---QDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAV 93

  Fly   173 ADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYG 237
            .||.|:.|||..:.:..:.|.|..|...||.|::.|:.|.|||||:||.|::|||..|.|.:.|.
Human    94 TDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYS 158

  Fly   238 RWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTP-TYAVVSSC 301
            ...|.:.|.:.||.:|:.:..:|..|......:.::         :...|.::... .|.|.|:.
Human   159 AKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEE---------EVSECVVNTDHILYTVYSTV 214

  Fly   302 ISFYFPCVVMIGIYCRLYCYAQKHV------KSIKAVTR-------PGEVAE----KQRYKSIRR 349
            .:||||.:::|.:|.|:|..|:..:      ::.|.:||       ||..:.    ..|...:..
Human   215 GAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPS 279

  Fly   350 PKNQP---KKFKVRNLHTHSSPYHVSD-------------HKAAVTVGVIMGVFLICWVPFFCVN 398
            ....|   .:.|||          |||             .||..|:|:|:|.|::||:|||.::
Human   280 ESGSPVYVNQVKVR----------VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIIS 334

  Fly   399 ITAAFCKTCIGGQ--TFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            :....||......  .|...|||||.||..|||||::.|::|:.||.:::..:
Human   335 LVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	101/347 (29%)
		TM helix 1	130..156	CDD:320193	4/25 (16%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	11/29 (38%)
		TM helix 6	371..401	CDD:320193	15/42 (36%)
		TM helix 7	410..435	CDD:320193	13/26 (50%)
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	103/352 (29%)
		TM helix 1	51..77	CDD:320455	4/25 (16%)
		TM helix 2	84..110	CDD:320455	11/25 (44%)
		TM helix 3	122..152	CDD:320455	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	6/22 (27%)
		TM helix 5	205..234	CDD:320455	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		3/21 (14%)
		TM helix 6	307..337	CDD:320455	12/29 (41%)
		TM helix 7	348..373	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369		3/3 (100%)