Protein Alignment Dop1R1 and HTR1A

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 124/396 - (31%)
• Similarity: 185/396 - (46%)
• Gaps: 95/396 - (23%)

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            |:..:.|..|||.:|.||..|..||..||||:.:.|..:.|||:.||.|:.||:..|.:..:|..
Human    37 VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK 101

  Fly   194 WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAF 258
            |..|...||.::|.||:|.|:|||:||||::|||..|.||:.|....|.|.|...|:..||:...
Human   102 WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFL 166

  Fly   259 VSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQ 323
            :| :|..||...|      ||.... ..|.:.....|.:.|:..:||.|.::|:.:|.|::..|:
Human   167 IS-IPPMLGWRTP------EDRSDP-DACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAAR 223

  Fly   324 KHV-KSIKAVTRPGEVAEKQRYKSIRRPKNQPKK------------------------------- 356
            ..: |::|.|.:.|  |:.:...|   |..||||
Human   224 FRIRKTVKKVEKTG--ADTRHGAS---PAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQ 283

  Fly   357 ------FKVRNLH-THSSPYHV---------------------------------SDHKAAVTVG 381
                  .:|..:| ..:|..|:                                 .:.|...|:|
Human   284 GDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLG 348

  Fly   382 VIMGVFLICWVPFFCVNITAAFCK------TCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRD 440
            :|||.|::||:|||.|.:...||:      |.:|.    |:.|||||||..||:||:.|||:|::
Human   349 IIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGA----IINWLGYSNSLLNPVIYAYFNKDFQN 409

  Fly   441 AFKRIL 446
            |||:|:
Human   410 AFKKII 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	119/389 (31%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	7/21 (33%)
		TM helix 5	292..321	CDD:320193	8/28 (29%)
		TM helix 6	371..401	CDD:320193	13/62 (21%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		7tmA_5-HT1A_vertebrates	37..411	CDD:320453	120/390 (31%)
		TM helix 1	38..64	CDD:320453	10/25 (40%)
		TM helix 2	71..97	CDD:320453	10/25 (40%)
		TM helix 3	109..139	CDD:320453	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	7/22 (32%)
		TM helix 5	192..221	CDD:320453	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262		8/31 (26%)
		TM helix 6	338..368	CDD:320453	13/29 (45%)
		TM helix 7	379..404	CDD:320453	14/28 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)