Protein Alignment Dop1R1 and Dop2R

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 686
• Identity: 156/686 - (22%)
• Similarity: 225/686 - (32%)
• Gaps: 288/686 - (41%)

  Fly    15 VGSVAATVATSTTSSISSSTTIINTSSATTIGGNHTSGSTGFSTNSTLLD--ADHLPLQLTTAKV 77
            :|:..|...||.....|....:....:.|..||...:|.:|.||...||:  .|:.|
  Fly   255 LGNRTAPSTTSYDGGGSGDVGVAGGLAGTAGGGVGGAGGSGGSTFMLLLENFNDYFP-------- 311

  Fly    78 DLDIEIDIQLLTNGYDGTT--------------------------LTSFYNESSWTNASEMDTIV 116
                         .|:|:|                          ||..|.:....|.:.....:
  Fly   312 -------------NYNGSTVSGTSTIAPGVAITGSRGSGLLLEQNLTGLYLDGYRLNCTNETLNL 363

  Fly   117 GEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLV 181
            .:....|.:|......:.|.:...|::.|||||.|::..||||:.:.|.|:.|||||||.||.:|
  Fly   364 TDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVV 428

  Fly   182 MTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAV 246
            |.||....:.|.|......||.::|.||:|||:||.||.|||:||||.:..|::|.:....|...
  Fly   429 MPFAVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVC 493

  Fly   247 ITIAAIWLLAAFVSFVPISLGIH-----RPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYF 306
            :||..:|.::|.:. .||.||::     .||             .||. ....:.:.||..|||.
  Fly   494 LTILLVWAISAAIG-SPIVLGLNNTPNREPD-------------VCAF-YNADFILYSSLSSFYI 543

  Fly   307 PCVVMIGIYCRLY---------------------------------------------------- 319
            ||::|:.:|..::
  Fly   544 PCIIMVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETALDSSRHASRILP 608

  Fly   320 --------------------------C-------------------------------------- 320
                                      |
  Fly   609 DEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQPQLVVAD 673

  Fly   321 --------YAQKHVKSIKAVTRP------------------------GEVAEKQRYKSIRRP--- 350
                    ||..:|..:.|...|                        |...::....|.|||
  Fly   674 PNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQRRPTGD 738

  Fly   351 ---------------------------------------------------------KN-QPKKF 357
                                                                     || |..:|
  Fly   739 DSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKNSQASRF 803

  Fly   358 KVRNLHTHSSPYH-----VSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFC----KTCIGGQT- 412
            .:..:|..|....     ..:.||..|:.:::||||.||:|||..||..|.|    |.|..|.|
  Fly   804 TIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDCRPGLTA 868

  Fly   413 FKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTM 448
            :.:.|||||.||..||:||:|||.|||.|||:|:.|
  Fly   869 YMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIMHM 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	126/535 (24%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	15/25 (60%)
		TM helix 3	201..231	CDD:320193	19/29 (66%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	10/152 (7%)
		TM helix 6	371..401	CDD:320193	14/29 (48%)
		TM helix 7	410..435	CDD:320193	14/25 (56%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	72/203 (35%)
		TM helix 1	377..403	CDD:320181	8/25 (32%)
		TM helix 2	410..436	CDD:320181	15/25 (60%)
		TM helix 3	448..478	CDD:320181	19/29 (66%)
		TM helix 4	490..513	CDD:320181	7/23 (30%)
		TM helix 5	529..558	CDD:320181	9/28 (32%)
		7tm_GPCRs	<822..898	CDD:475119	37/75 (49%)
		TM helix 6	828..850	CDD:320181	10/21 (48%)
		TM helix 7	866..891	CDD:320181	13/24 (54%)