DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop1R1 and HRH2

DIOPT Version :9

Sequence 1:NP_001262563.1 Gene:Dop1R1 / 41726 FlyBaseID:FBgn0011582 Length:560 Species:Drosophila melanogaster
Sequence 2:NP_001354640.1 Gene:HRH2 / 3274 HGNCID:5183 Length:422 Species:Homo sapiens


Alignment Length:385 Identity:121/385 - (31%)
Similarity:188/385 - (48%) Gaps:84/385 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            :.:.:.|:|||.::||||::||||:...|.||.:.|.|:.||||.||.:..||:.|:.:..|...
Human    19 ITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCK 83

  Fly   194 WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAF 258
            |.||..||:.:.:.|||..|||||||..||:|||..:.|||||...||.....|::..||:::..
Human    84 WSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISIT 148

  Fly   259 VSFVPISLGIHRPDQPLIFEDNGKKYPT--CALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCY 321
            :||:.|.||.:..:     |.:...:.|  |.:.:...|.:|...::||.|.::|...|.|::..
Human   149 LSFLSIHLGWNSRN-----ETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKV 208

  Fly   322 AQ------KHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTV 380
            |:      .|:.|.||.|                                     :.:|||.||:
Human   209 ARDQAKRINHISSWKAAT-------------------------------------IREHKATVTL 236

  Fly   381 GVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFK-----ILTWLGYSNSAFNPIIYSIFNKEFRD 440
            ..:||.|:|||.|:|    ||...:...|.....     |:.||||:|||.|||:|:..|::||.
Human   237 AAVMGAFIICWFPYF----TAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRT 297

  Fly   441 AFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSA-ELEQVSAIXPK 499
            .::::      :||     .:..|||.:             .|.||:| :|.:..:. |:
Human   298 GYQQL------FCC-----RLANRNSHK-------------TSLRSNASQLSRTQSREPR 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R1NP_001262563.1 7tm_4 134..>266 CDD:304433 60/131 (46%)
7tm_1 145..431 CDD:278431 100/298 (34%)
HRH2NP_001354640.1 7tmA_Histamine_H2R 19..299 CDD:320179 110/325 (34%)
TM helix 1 21..45 CDD:320179 12/23 (52%)
TM helix 2 54..76 CDD:320179 11/21 (52%)
TM helix 3 92..114 CDD:320179 11/21 (52%)
TM helix 4 137..153 CDD:320179 5/15 (33%)
TM helix 5 180..203 CDD:320179 6/22 (27%)
TM helix 6 233..255 CDD:320179 12/25 (48%)
TM helix 7 267..292 CDD:320179 12/24 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 316..340 6/18 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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