Protein Alignment Dop1R1 and Htr2b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_058946.2
• Gene: Htr2b / 29581
• RGDID: 61801
• Length: 479
• Species: Rattus norvegicus
• Alignment Length: 460
• Identity: 127/460 - (27%)
• Similarity: 200/460 - (43%)
• Gaps: 103/460 - (22%)

  Fly    83 IDIQLLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNI 147
            |...:|....|...||......:.:.|.||......:...:...::::..:     |..::.|||
  Rat    13 ISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAV-----IIPTIGGNI 72

  Fly   148 LVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWIFGAQFCDTWVAFDVMC 211
            ||.||:..|:.|:...|.||.|||:|||.|...||..|.:..:. ..|......|..|:..||:.
  Rat    73 LVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLF 137

  Fly   212 STASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSF-VPISLGIHRPDQPL 275
            |||||::|||||:||||.||.|::..:..:|..|.:.|..:||::..::. |||. ||   :..:
  Rat   138 STASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIK-GI---EADV 198

  Fly   276 IFEDNGKKYPTCAL--DLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEV 338
            :...|    .||.|  |...::.:..|..:|:.|..:||..|          ..:|.|:
  Rat   199 VNAHN----ITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTY----------FLTIHAL------ 243

  Fly   339 AEKQRYKSIRRPKNQPKKFKV-----RNLHTHSSPYHV--------------------------- 371
             .|:.|....||..:..::.|     |...:.|||..:
  Rat   244 -RKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMAMLDGSHKDKILPNSIDETLMRRMSSA 307

  Fly   372 ---------SDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQT-----FKILTWLGYS 422
                     ::.:|:..:|::...||:.|.|||..|:|.|.|.:|  .||     .:|..|:||.
  Rat   308 GKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSC--NQTTLKTLLQIFVWVGYV 370

  Fly   423 NSAFNPIIYSIFNKEFRDAFKRILTMRNPWC-------------CAQDV--GNIHPRNSDRFITD 472
            :|..||:||::|||.||:||.|.:|     |             |:..:  ||....|| :|.|.
  Rat   371 SSGVNPLIYTLFNKTFREAFGRYIT-----CNYQATKSVKVLRKCSSTLYFGNSMVENS-KFFTK 429

  Fly   473 YAAKN 477
            :..:|
  Rat   430 HGIRN 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	106/361 (29%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	18/29 (62%)
		TM helix 4	243..265	CDD:320193	6/22 (27%)
		TM helix 5	292..321	CDD:320193	6/28 (21%)
		TM helix 6	371..401	CDD:320193	9/65 (14%)
		TM helix 7	410..435	CDD:320193	11/29 (38%)
Htr2b	NP_058946.2	7tm_GPCRs	54..397	CDD:475119	110/379 (29%)
		TM helix 1	56..80	CDD:410628	8/28 (29%)
		TM helix 2	89..111	CDD:410628	12/21 (57%)
		TM helix 3	128..150	CDD:410628	12/21 (57%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	173..189	CDD:410628	3/15 (20%)
		[DE]RFG motif, may stabilize a conformation that preferentially activates signaling via beta-arrestin family members. /evidence=ECO:0000250|UniProtKB:P41595	211..214		1/2 (50%)
		TM helix 5	214..237	CDD:410628	6/32 (19%)
		TM helix 6	322..344	CDD:410628	7/21 (33%)
		TM helix 7	358..383	CDD:410628	9/24 (38%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	375..379		2/3 (67%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P41595	477..479