Protein Alignment Dop1R1 and Drd3

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_058836.1
• Gene: Drd3 / 29238
• RGDID: 2521
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 421
• Identity: 127/421 - (30%)
• Similarity: 184/421 - (43%)
• Gaps: 125/421 - (29%)

  Fly   138 LIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWIFGAQFC 201
            ||...:.||.|||.|:..||:|:...|..:.|||:|||.||:|||.:....::. |.|.|....|
  Rat    39 LILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICC 103

  Fly   202 DTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRY----GRWVTRRVAVITIAAIWLLAAFVSFV 262
            |.:|..|||..|||||||||||:|||..:..|:.|    |:...||||:: |.|:|:||..|| .
  Rat   104 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALM-ITAVWVLAFAVS-C 166

  Fly   263 PISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVK 327
            |:..|.:....|.|          |::. .|.:.:.||.:|||.|..|.:.:|.|:|...::..:
  Rat   167 PLLFGFNTTGDPSI----------CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQR 220

  Fly   328 SIKAVT---------RPG-------------------------------EVAEKQ---------- 342
            . :.:|         |||                               .:.:||
  Rat   221 K-RILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLL 284

  Fly   343 ----------------RYKSI--------------------RRPKNQ------PK-KFKVRNLHT 364
                            ||.||                    .|.:|.      || ..:||.|..
  Rat   285 SHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSN 349

  Fly   365 -------HSSPYH-----VSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-IGGQTFKIL 416
                   ...|..     :.:.||...|.:::|.|::||:|||..::....|:.| :..:.::..
  Rat   350 GRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRAT 414

  Fly   417 TWLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            |||||.|||.||:||:.||.|||.||.:||:
  Rat   415 TWLGYVNSALNPVIYTTFNVEFRKAFLKILS 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	123/414 (30%)
		TM helix 1	130..156	CDD:320193	8/17 (47%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	11/21 (52%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Drd3	NP_058836.1	7tmA_D3_dopamine_R	30..440	CDD:320436	123/414 (30%)
		TM helix 1	31..57	CDD:320436	8/17 (47%)
		TM helix 2	64..87	CDD:320436	12/22 (55%)
		TM helix 3	103..133	CDD:320436	20/29 (69%)
		TM helix 4	150..168	CDD:320436	9/19 (47%)
		TM helix 5	185..210	CDD:320436	9/24 (38%)
		TM helix 6	368..398	CDD:320436	10/29 (34%)
		TM helix 7	408..433	CDD:320436	12/24 (50%)