Protein Alignment Dop1R1 and drd3

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_005162730.1
• Gene: drd3 / 282554
• ZFINID: ZDB-GENE-021119-1
• Length: 472
• Species: Danio rerio
• Alignment Length: 468
• Identity: 140/468 - (29%)
• Similarity: 202/468 - (43%)
• Gaps: 127/468 - (27%)

  Fly    95 TTLTSFYNESSWT-NASEMDTIVGEEPEPLSLVSIV---VVGIFLSVLIFLSVAGNILVCLAIYT 155
            :||.:.::...|. |.||.....|....|.|.|...   ...:..|:||...|.||:|||:|:..
Zfish    16 STLMAMFSSGEWLWNDSEHSFTPGGNYSPASGVEEAKRNYYAMLYSLLILAIVFGNVLVCIAVLR 80

  Fly   156 ERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWIFGAQFCDTWVAFDVMCSTASILNL 219
            ||:|:...|..:.|||:|||.||||||.:|...::: |.|:|...:|:.:|..|||..|||||||
Zfish    81 ERALQTTTNYLVVSLAVADLLVASLVMPWAVYLEVVGGAWLFSRLYCNVFVTLDVMMCTASILNL 145

  Fly   220 CAISMDRYIHIKDPLRYGRWVTRRVAV-ITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKK 283
            ||||:|||..:..|:.|....:.|..| :.||.:|:||..|| .|:..|.:..|.|.:
Zfish   146 CAISIDRYTAVVMPVLYNTTHSSRKRVSVMIATVWVLAFAVS-CPLLFGFNTTDDPAV------- 202

  Fly   284 YPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEV---------- 338
               |::. .|.:.:.||.:|||.|..|.:.:|.|:|.:.::..|.|......|:|
Zfish   203 ---CSIS-NPDFVIYSSVVSFYLPFAVTLLVYVRIYIFLRRRRKKITFRQGSGKVQPASAPPSVE 263

  Fly   339 --------AEKQRYKSIR------------------------RPKNQPKK--------------- 356
                    .||:....||                        ||:..|.:
Zfish   264 MCLQDDAHKEKRDLSPIRINVITESKEQVIRPRLLANCLRRKRPQTAPAENSLLPPVITLNYCSI 328

  Fly   357 --------------------------------FKVRNLHTHSS-------------------PYH 370
                                            .|:.|..||:|                   ..|
Zfish   329 SQASFARTEQDANREEEEGGDEEQVAVRSCEVKKLANGRTHTSLRPPRAAHAMVCPSQARCRSMH 393

  Fly   371 VSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-IGGQTFKILTWLGYSNSAFNPIIYSIF 434
            ..:.||...:.:::|||||||:|||..:|....|:.| |..:.:...|||||.|||.||:||:.|
Zfish   394 SKEKKATQMLAIVLGVFLICWLPFFVTHILNTHCRACHIPPEVYSAFTWLGYVNSALNPVIYTTF 458

  Fly   435 NKEFRDAFKRILT 447
            |.|||.||.:||:
Zfish   459 NIEFRRAFIKILS 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	126/422 (30%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	14/25 (56%)
		TM helix 3	201..231	CDD:320193	19/29 (66%)
		TM helix 4	243..265	CDD:320193	10/22 (45%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	13/29 (45%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
drd3	XP_005162730.1	7tmA_D3_dopamine_R	54..466	CDD:320436	126/423 (30%)
		TM helix 1	55..81	CDD:320436	10/25 (40%)
		TM helix 2	88..111	CDD:320436	13/22 (59%)
		TM helix 3	127..157	CDD:320436	19/29 (66%)
		TM helix 4	172..190	CDD:320436	8/18 (44%)
		TM helix 5	207..232	CDD:320436	9/24 (38%)
		TM helix 6	394..424	CDD:320436	13/29 (45%)
		TM helix 7	434..459	CDD:320436	12/24 (50%)