Protein Alignment Dop1R1 and adra2db

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_919346.1
• Gene: adra2db / 266755
• ZFINID: ZDB-GENE-021010-5
• Length: 415
• Species: Danio rerio
• Alignment Length: 426
• Identity: 130/426 - (30%)
• Similarity: 215/426 - (50%)
• Gaps: 91/426 - (21%)

  Fly    93 DGTTLTSFY-NESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTE 156
            |.:|:|... |.|..||.:....:     .|.|..:.|::.:.::|:|.:::.||:||.:|::|.
Zfish     2 DLSTITFLLPNSSEDTNGTSAPRL-----PPHSQCASVLIVLVVTVIILVTIVGNVLVVVAVFTS 61

  Fly   157 RSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCA 221
            |:||...||||.|||.||:.||:||:.|:..|:::|||..|:.:|..::|.||:..|:||::|||
Zfish    62 RALRAPQNLFLVSLAAADILVATLVIPFSLANEVMGYWYLGSTWCAFYLALDVLFCTSSIVHLCA 126

  Fly   222 ISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPT 286
            ||:|||..:...:.|....|.|...|.|..:|:::|.:||.|:.:..|...:
Zfish   127 ISLDRYWSVTKAVSYNLKRTPRRIKIMITVVWVISAVISFPPLLMTKHDELE------------- 178

  Fly   287 CALDLTPTYAVVSSCI-SFYFPCVVMIGIYCRLY--------------------------CYAQK 324
            |.|: ..|:.::|||| ||:.|.::||.:|||:|                          |:.:|
Zfish   179 CLLN-NETWYILSSCIVSFFAPGLIMILVYCRIYRVAKQRASTVFVAKNGMERQPSQSETCFVRK 242

  Fly   325 HVKSIKAVT--------RPGEVAE--------KQRYKSIRRPKNQ--------PK---------- 355
            ....:::.:        |.||:.:        ..|:::.|..|::        ||
Zfish   243 GKSEVESPSSHSSGSRERKGELDDIDLEESSVSNRHRNSRFAKSRKVEGAQSCPKPNGRLSWACS 307

  Fly   356 -------KFKVRNLHTHSSPY-HVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFC-KTC-IGG 410
                   :.:.|.|....|.. .:.:.:....:.|:||||::||.|||......|.| |:| |..
Zfish   308 RASELEQEPRARQLSLSKSKLAQMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAICRKSCTIPD 372

  Fly   411 QTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
            ..|.:..|:||.||:.|||||:|||::||.|||:|:
Zfish   373 SLFNLFFWIGYCNSSVNPIIYTIFNRDFRKAFKKIM 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	116/382 (30%)
		TM helix 1	130..156	CDD:320193	7/25 (28%)
		TM helix 2	163..189	CDD:320193	14/25 (56%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	14/55 (25%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
adra2db	NP_919346.1	7tmA_alpha-2D_AR	59..404	CDD:320447	109/358 (30%)
		TM helix 2	68..94	CDD:320447	14/25 (56%)
		TM helix 3	106..136	CDD:320447	15/29 (52%)
		TM helix 4	148..171	CDD:320447	8/22 (36%)
		TM helix 5	184..213	CDD:320447	14/28 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..299		10/64 (16%)
		TM helix 6	331..361	CDD:320447	10/29 (34%)
		TM helix 7	372..397	CDD:320447	12/24 (50%)