DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and Htr4

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_036985.2	Gene:	Htr4 / 25324	RGDID:	2850	Length:	388	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	117/341 - (34%)
Similarity:	174/341 - (51%)	Gaps:	30/341 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRI-GNLFLASLAIADLFVASLVMTF 184
            |....|..||:..|.:::|.:::.||:||.:|:..:|.||:| .|.|:.|||.|||.|:.|||.|
  Rat    12 EGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPF 76

  Fly   185 AGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHI-KDPLRYGRWVTRRVAVIT 248
            ..:..:...|.:|..||....:.||:.:||||.:||.||:|||..| ..||.|...:|.....:.
  Rat    77 GAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALM 141

  Fly   249 IAAIWLLAAFVSFVPI-----SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPC 308
            :...|::..|:||:||     ::||....:...|..|... ..|...:...||:..|.::||.|.
  Rat   142 LGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNS-TFCVFMVNKPYAITCSVVAFYIPF 205

  Fly   309 VVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSD 373
            ::|:..|.|:|..|::|.:.|:.:.|.|..:|.       ||:...:         ||:....::
  Rat   206 LLMVLAYYRIYVTAKEHAQQIQMLQRAGATSES-------RPQTADQ---------HSTHRMRTE 254

  Fly   374 HKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEF 438
            .|||.|:.||||.|..||.|||..||...|....:..:.:....||||.||..||.:|:..||.|
  Rat   255 TKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSF 319

  Fly   439 RDAFKRILTMRNPWCC 454
            |.||..||      ||
  Rat   320 RRAFLIIL------CC 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	52/138 (38%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	100/292 (34%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	109/319 (34%)
		TM helix 1	22..46	CDD:320184	7/23 (30%)
		TM helix 2	56..78	CDD:320184	13/21 (62%)
		TM helix 3	94..116	CDD:320184	9/21 (43%)
		TM helix 4	140..156	CDD:320184	4/15 (27%)
		TM helix 5	190..213	CDD:320184	7/22 (32%)
		TM helix 6	258..280	CDD:320184	12/21 (57%)
		TM helix 7	291..316	CDD:320184	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010