Protein Alignment Dop1R1 and Drd5

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_036900.2
• Gene: Drd5 / 25195
• RGDID: 2523
• Length: 475
• Species: Rattus norvegicus
• Alignment Length: 445
• Identity: 158/445 - (35%)
• Similarity: 222/445 - (49%)
• Gaps: 82/445 - (18%)

  Fly   110 SEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIA 173
            :::|...| ...||....:|..|: |::||..::.||:|||.||...|.|| ::.|:|:.|||::
  Rat    22 AQVDAPAG-SATPLGPAQVVTAGL-LTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVS 84

  Fly   174 DLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGR 238
            |||||.|||.:..|.::.|||.||. |||.|||||:|||||||||||.||:|||..|..|.||.|
  Rat    85 DLFVALLVMPWKAVAEVAGYWPFGT-FCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYER 148

  Fly   239 WVTRRVAVITIAAIWLLAAFVSFVPISLGIHRP------DQPLIFEDNGKKY----------PTC 287
            .:|:|||::.:...|.|:..:||:|:.|..||.      .:.|:  .||..:          ..|
  Rat   149 KMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLL--SNGTPWEEGWELEGRTENC 211

  Fly   288 ALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRP-- 350
            ...|..|||:.||.||||.|..:||..|.|:|..||..::.|.::.|..|.|:..|.:....|
  Rat   212 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDP 276

  Fly   351 ------KNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKT--- 406
                  |.:.|.||                    |:.:|||||:.||:|||.:|....||.:
  Rat   277 SLRASIKKETKVFK--------------------TLSMIMGVFVCCWLPFFILNCMVPFCSSGDA 321

  Fly   407 --------CIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL-----TMRNPWCCAQDV 458
                    |:...||.|..|.|::||:.|||||: ||.:||..|.::|     ..|.|.......
  Rat   322 EGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLGCSHFCFRTPVQTVNIS 385

  Fly   459 GNIHPRNSDR-FITDYAAKNVVVMNSGRSSAELE--------------QVSAIXP 498
            ..:...|.|. |..:.||..|.::.:..||.:.|              |:|...|
  Rat   386 NELISYNQDTVFHKEIAAAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	137/347 (39%)
		TM helix 1	130..156	CDD:320193	11/25 (44%)
		TM helix 2	163..189	CDD:320193	14/25 (56%)
		TM helix 3	201..231	CDD:320193	23/29 (79%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	15/28 (54%)
		TM helix 6	371..401	CDD:320193	12/29 (41%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Drd5	NP_036900.2	7tm_GPCRs	39..364	CDD:475119	138/349 (40%)
		TM helix 1	41..65	CDD:410628	11/24 (46%)
		TM helix 2	75..97	CDD:410628	13/21 (62%)
		TM helix 3	112..134	CDD:410628	18/21 (86%)
		TM helix 4	157..173	CDD:410628	4/15 (27%)
		TM helix 5	217..240	CDD:410628	12/22 (55%)
		TM helix 6	289..311	CDD:410628	13/41 (32%)
		TM helix 7	333..358	CDD:410628	13/25 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..443		5/26 (19%)