DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R1 and Drd5

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_036900.1	Gene:	Drd5 / 25195	RGDID:	2523	Length:	475	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	157/445 - (35%)
Similarity:	221/445 - (49%)	Gaps:	82/445 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIA 173
            :::|...| ...||....:|..|: |::||..::.||:|||.||...|.|| ::.|:|:.|||::
  Rat    22 AQVDAPAG-SATPLGPAQVVTAGL-LTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVS 84

  Fly   174 DLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGR 238
            |||||.|||.:..|.::.|||.||. |||.|||||:|||||||||||.||:|||..|..|.||.|
  Rat    85 DLFVALLVMPWKAVAEVAGYWPFGT-FCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYER 148

  Fly   239 WVTRRVAVITIAAIWLLAAFVSFVPISLGIHRP------DQPLIFEDNGKKY----------PTC 287
            .:|:|||::.:...|.|:..:||:|:.|..||.      .:.|:  .||..:          ..|
  Rat   149 KMTQRVALVMVGLAWTLSILISFIPVQLNWHRDKAGSQGQEGLL--SNGTPWEEGWELEGRTENC 211

  Fly   288 ALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRP-- 350
            ...|..|||:.||.||||.|..:||..|.|:|..||..::.|.::.|..|.|:..|.:....|
  Rat   212 DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDP 276

  Fly   351 ------KNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKT--- 406
                  |.:.|.||                    |:.:|||||:.||:|||.:|....||.:
  Rat   277 SLRASIKKETKVFK--------------------TLSMIMGVFVCCWLPFFILNCMVPFCSSGDA 321

  Fly   407 --------CIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL-----TMRNPWCCAQDV 458
                    |:...||.|..|.|::||:.|||||: ||.:||..|.::|     ..|.|.......
  Rat   322 EGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLGCSHFCFRTPVQTVNIS 385

  Fly   459 GNIHPRNSDR-FITDYAAKNVVVMNSGRSSAELE--------------QVSAIXP 498
            ..:...|.|. |..:.|...|.::.:..||.:.|              |:|...|
  Rat   386 NELISYNQDTVFHKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTP 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	70/132 (53%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	127/321 (40%)
Drd5	NP_036900.1	7tm_1	55..354	CDD:278431	127/321 (40%)
		7tm_4	<121..>173	CDD:304433	28/51 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..443		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2500
eggNOG	1	0.900	-	-		E33208_3B9BF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm44978
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830