DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dop1R1 and Htr2c

DIOPT Version :10

Sequence 1:NP_001262563.1 Gene:Dop1R1 / 41726 FlyBaseID:FBgn0011582 Length:560 Species:Drosophila melanogaster
Sequence 2:NP_036897.2 Gene:Htr2c / 25187 RGDID:2848 Length:460 Species:Rattus norvegicus


Alignment Length:430 Identity:125/430 - (29%)
Similarity:202/430 - (46%) Gaps:87/430 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 GFSTNSTLLDADHLPLQLTTAKVDLDIEIDIQLLT---NGYDGTTLTSFYN-ESSWTNASEMDTI 115
            |.:..|.|:   || :.|...:.|:.|.....::|   |..||..|..|.: ..:|         
  Rat     5 GNAVRSLLM---HL-IGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNW--------- 56

  Fly   116 VGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASL 180
                 ..||:|          |:|.:::.|||||.:|:..|:.|....|.||.||||||:.|..|
  Rat    57 -----PALSIV----------VIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLL 106

  Fly   181 VMTFAGVNDLLGY-WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRV 244
            ||..:.:..|..| |......|..|::.||:.|||||::|||||:|||:.|::|:.:.|:.:|..
  Rat   107 VMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTK 171

  Fly   245 AVITIAAIWLLAAFVSFVPIS-LGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPC 308
            |::.||.:|.::..|| |||. :|:.  |:..:|.:|    .||.|: .|.:.::.|.::|:.|.
  Rat   172 AIMKIAIVWAISIGVS-VPIPVIGLR--DESKVFVNN----TTCVLN-DPNFVLIGSFVAFFIPL 228

  Fly   309 VVMIGIYCR----------------------------LYCYAQKHVKSIKAVTRPGEVAEKQRYK 345
            .:|:..|..                            |.|..:|:....:....|....:.:|.|
  Rat   229 TIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKK 293

  Fly   346 SIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFC-KTC-- 407
            ..:||:...:...             ::.||:..:|::..||||.|.|||..||.:..| |.|  
  Rat   294 KEKRPRGTMQAIN-------------NEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQ 345

  Fly   408 -IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
             :..:...:..|:||..|..||::|::|||.:|.||.:.|
  Rat   346 KLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYL 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dop1R1NP_001262563.1 7tmA_Ap5-HTB1-like 130..442 CDD:320193 104/345 (30%)
TM helix 1 130..156 CDD:320193 8/25 (32%)
TM helix 2 163..189 CDD:320193 13/25 (52%)
TM helix 3 201..231 CDD:320193 17/29 (59%)
TM helix 4 243..265 CDD:320193 8/21 (38%)
TM helix 5 292..321 CDD:320193 7/56 (13%)
TM helix 6 371..401 CDD:320193 13/29 (45%)
TM helix 7 410..435 CDD:320193 7/24 (29%)
Htr2cNP_036897.2 7tmA_5-HT2C 55..387 CDD:341346 111/376 (30%)
TM helix 1 56..82 CDD:341346 12/49 (24%)
TM helix 2 89..115 CDD:341346 13/25 (52%)
TM helix 3 128..158 CDD:341346 17/29 (59%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595 152..154 1/1 (100%)
TM helix 4 170..193 CDD:341346 9/23 (39%)
TM helix 5 212..241 CDD:341346 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 276..301 5/24 (21%)
TM helix 6 306..336 CDD:341346 13/42 (31%)
TM helix 7 349..374 CDD:341346 7/24 (29%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595 366..370 2/3 (67%)
PDZ-binding 458..460
Blue background indicates that the domain is not in the aligned region.

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