Protein Alignment Dop1R1 and Htr1b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_071561.1
• Gene: Htr1b / 25075
• RGDID: 2846
• Length: 386
• Species: Rattus norvegicus
• Alignment Length: 378
• Identity: 108/378 - (28%)
• Similarity: 176/378 - (46%)
• Gaps: 58/378 - (15%)

  Fly   108 NASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAI 172
            |.|..|.|.   .:.::|...|::...|:::...:...|..|...:|..|.|....|..:||||:
  Rat    28 NCSADDYIY---QDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAV 89

  Fly   173 ADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYG 237
            .||.|:.|||..:.:..:.|.|..|...||.|::.|:.|.||||::||.|::|||..|.|.:.|.
  Rat    90 TDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYS 154

  Fly   238 RWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPT-YAVVSSC 301
            ...|.:.|.|.|..:|:.:..:|..|......:.::.::         .|.::.... |.|.|:.
  Rat   155 AKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVL---------DCFVNTDHVLYTVYSTV 210

  Fly   302 ISFYFPCVVMIGIYCRLYCYAQKHV------KSIKAVTR-------PGEVAE----KQRYKSIRR 349
            .:||.|.:::|.:|.|:|..|:..:      |:.|.:||       ||..:.    ..|...:..
  Rat   211 GAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPS 275

  Fly   350 PKNQP---KKFKVRNLHTHSSPYHVSD-------------HKAAVTVGVIMGVFLICWVPFFCVN 398
            ....|   .:.|||          |||             .||..|:|:|:|.|::||:|||.::
  Rat   276 ESGSPVYVNQVKVR----------VSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIIS 330

  Fly   399 ITAAFCK-TC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            :....|| .| .....|....||||.||..|||||::.|::|:.||.:::..:
  Rat   331 LVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	100/347 (29%)
		TM helix 1	130..156	CDD:320193	4/25 (16%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	10/29 (34%)
		TM helix 6	371..401	CDD:320193	15/42 (36%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Htr1b	NP_071561.1	7tmA_5-HT1B_1D	42..376	CDD:320455	102/352 (29%)
		TM helix 1	47..73	CDD:320455	4/25 (16%)
		TM helix 2	80..106	CDD:320455	11/25 (44%)
		TM helix 3	118..148	CDD:320455	15/29 (52%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	6/22 (27%)
		TM helix 5	201..230	CDD:320455	10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..276		3/20 (15%)
		TM helix 6	303..333	CDD:320455	12/29 (41%)
		TM helix 7	344..369	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		3/3 (100%)