Protein Alignment Dop1R1 and Adra2b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_612514.2
• Gene: Adra2b / 24174
• RGDID: 2057
• Length: 453
• Species: Rattus norvegicus
• Alignment Length: 451
• Identity: 128/451 - (28%)
• Similarity: 197/451 - (43%)
• Gaps: 125/451 - (27%)

  Fly   118 EEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVM 182
            :..||.|:.:...:...::.||..::.||.||.||:.|.||||...||||.|||.||:.||:|::
  Rat     7 DHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 71

  Fly   183 TFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVI 247
            .|:..|:|||||.|...:|:.::|.||:..|:||::|||||:|||..:...|.|....|.|....
  Rat    72 PFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKC 136

  Fly   248 TIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMI 312
            .|..:||:||.:|..|:   |::.||    ....:..|.|.|:....|.:.||..||:.||::||
  Rat   137 IILTVWLIAAVISLPPL---IYKGDQ----RPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMI 194

  Fly   313 GIYCRLYCYAQK-HVKSIKAVTRPGEVAEKQ---------------------------------- 342
            .:|.|:|..|:: |.:.:.|....||...|:
  Rat   195 LVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPP 259

  Fly   343 -------------------RYKSIRR--------------------------------------- 349
                               .:.::.|
  Rat   260 REKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPAS 324

  Fly   350 ----PKNQPKKFKV-----------RNLHTHSSPY-----HVSDHKA-AVTVGVIMGVFLICWVP 393
                |..||:..:|           :|:...|..:     .:|..|. ...:.|::|||::||.|
  Rat   325 VCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFP 389

  Fly   394 FFCVNITAAFC-KTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPW 452
            ||......|.| :.| :....|:...|:||.||:.||:||::||::||.||:|||.  .||
  Rat   390 FFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILC--RPW 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	118/427 (28%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	12/28 (43%)
		TM helix 6	371..401	CDD:320193	11/30 (37%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
Adra2b	NP_612514.2	7tmA_alpha2B_AR	12..440	CDD:320444	119/434 (27%)
		TM helix 1	19..45	CDD:320444	8/25 (32%)
		TM helix 2	52..78	CDD:320444	13/25 (52%)
		TM helix 3	90..120	CDD:320444	15/29 (52%)
		TM helix 4	132..155	CDD:320444	8/25 (32%)
		TM helix 5	174..203	CDD:320444	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	213..331		6/117 (5%)
		TM helix 6	367..397	CDD:320444	11/29 (38%)
		TM helix 7	408..433	CDD:320444	10/24 (42%)