Protein Alignment Dop1R1 and Gpr161

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001074595.1
• Gene: Gpr161 / 240888
• MGIID: 2685054
• Length: 558
• Species: Mus musculus
• Alignment Length: 381
• Identity: 95/381 - (24%)
• Similarity: 167/381 - (43%)
• Gaps: 53/381 - (13%)

  Fly    87 LLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCL 151
            |||......|::.   .||.:...|:..:...|......||..:..|.::||:.|   ||:::.:
Mouse    21 LLTASRGALTMSL---NSSLSYRKELSNLTATEGGEGGAVSEFIAIIIITVLVCL---GNLVIVV 79

  Fly   152 AIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASI 216
            .:|.:..|..:.|.|:.||.:::..::.||:.|...:.:...||||..:|:......::.|:||:
Mouse    80 TLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASM 144

  Fly   217 LNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPL-----I 276
            |.|..|::|||..:..|:.|...:|...||:.:..|| |.:.:..:|          ||     :
Mouse   145 LTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIW-LHSLIGCLP----------PLFGWSSV 198

  Fly   277 FEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEK 341
            ..|..|.....|....|.|.:........||.::|  :.|..:.:....||:.|.........|:
Mouse   199 EFDEFKWMCVAAWHQEPGYTIFWQIWCALFPFLIM--LVCYGFIFRVARVKARKVHCGTVVTVEE 261

  Fly   342 QRYKSIRRPKNQPKKFKVRNLHTHSSP------------YHVSDHKAAVTVGVIMGVFLICWVPF 394
            ...:|.|           :|..|.:|.            |..:..||.:|:.|::|.|::.|.|:
Mouse   262 DSQRSGR-----------KNSSTSTSSSGSRRNALQGVVYSANQCKALITILVVIGAFMVTWGPY 315

  Fly   395 FCVNIT--AAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTM 448
            ..| ||  |.:.|.|:........|||.::::..:|:||.::||..|   |.:|.|
Mouse   316 MVV-ITSEALWGKNCVSPTLETWATWLSFTSAICHPLIYGLWNKTVR---KELLGM 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	82/330 (25%)
		TM helix 1	130..156	CDD:320193	7/25 (28%)
		TM helix 2	163..189	CDD:320193	7/25 (28%)
		TM helix 3	201..231	CDD:320193	10/29 (34%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	6/28 (21%)
		TM helix 6	371..401	CDD:320193	11/31 (35%)
		TM helix 7	410..435	CDD:320193	6/24 (25%)
Gpr161	NP_001074595.1	7tmA_GPR161	58..364	CDD:320342	84/336 (25%)
		TM helix 1	58..84	CDD:320342	8/28 (29%)
		TM helix 2	91..116	CDD:320342	7/24 (29%)
		TM helix 3	129..159	CDD:320342	10/29 (34%)
		TM helix 4	171..193	CDD:320342	7/32 (22%)
		TM helix 5	214..243	CDD:320342	6/30 (20%)
		TM helix 6	292..322	CDD:320342	11/30 (37%)
		TM helix 7	332..357	CDD:320342	6/24 (25%)