DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and OR5T2

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001004746.2	Gene:	OR5T2 / 219464	HGNCID:	15296	Length:	318	Species:	Homo sapiens

Alignment Length:	345	Identity:	73/345 - (21%)
Similarity:	126/345 - (36%)	Gaps:	102/345 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 IFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLV-----MTFAGVNDLLG 192
            :||::.:| ::.||:.:.|.:..:..|.:....||:.|:..|...:|::     :.|...|.::.
Human    28 LFLAIYLF-TLMGNLGLILVVIRDSQLHKPMYYFLSMLSSVDACYSSVITPNMLVDFTTKNKVIS 91

  Fly   193 YWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRR----------VAVI 247
            :  .|   |...|.......|.....|.|::.|||:.|.:||.|...::.|          ||.|
Human    92 F--LG---CVAQVFLACSFGTTECFLLAAMAYDRYVAIYNPLLYSVSMSPRVYMPLINASYVAGI 151

  Fly   248 TIAAIWLLAAF-VSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYF-PCVV 310
            ..|.|..:|.| :||...: .|.|     :|.|..   |..|:..:.|:  .:..:.||| ..:.
Human   152 LHATIHTVATFSLSFCGAN-EIRR-----VFCDIP---PLLAISYSDTH--TNQLLLFYFVGSIE 205

  Fly   311 MIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLH------------ 363
            ::.|...|..|....:..:|..:..|           ||     |.|.....|
Human   206 LVTILIVLISYGLILLAILKMYSAEG-----------RR-----KVFSTCGAHLTGVSIYYGTIL 254

  Fly   364 ---THSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSA 425
               ...|..:.|||      .:|:.:|....:|.
Human   255 FMYVRPSSSYASDH------DMIVSIFYTIVIPL------------------------------- 282

  Fly   426 FNPIIYSIFNKEFRDAFKRI 445
            .||:|||:.||:.:|:.|::
Human   283 LNPVIYSLRNKDVKDSMKKM 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	37/147 (25%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	63/317 (20%)
OR5T2	NP_001004746.2	7tm_GPCRs	23..301	CDD:421689	72/342 (21%)
		TM helix 1	24..50	CDD:410628	6/22 (27%)
		TM helix 2	57..83	CDD:410628	5/25 (20%)
		TM helix 3	95..125	CDD:410628	8/29 (28%)
		TM helix 4	138..159	CDD:410628	5/20 (25%)
		TM helix 5	193..223	CDD:410628	6/29 (21%)
		TM helix 6	230..260	CDD:410628	6/45 (13%)
		TM helix 7	267..292	CDD:410628	10/61 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24247
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100