Protein Alignment Dop1R1 and Taar7a

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001010829.1
• Gene: Taar7a / 215856
• MGIID: 2685075
• Length: 358
• Species: Mus musculus
• Alignment Length: 320
• Identity: 98/320 - (30%)
• Similarity: 145/320 - (45%)
• Gaps: 50/320 - (15%)

  Fly   141 LSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWV 205
            |:|.||:||..:|...|.|....|..:||||.||..|...||.|:.|..:.|.|.||..:|....
Mouse    60 LAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSTVRSVEGCWYFGESYCKFHS 124

  Fly   206 AFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHR 270
            .|:.....:||.:||.||:||||.:.|||.|....|..|:...|...|||:...||..:..|.:
Mouse   125 CFEGSFCYSSIFHLCFISVDRYIAVSDPLTYPTRFTASVSGKCITFSWLLSIIYSFSLLYTGAN- 188

  Fly   271 PDQPLIFEDNGKKYPTCALDLTPTYAVVSSC-------------ISFYFPCVVMIGIYCRLYCYA 322
                    :.|.:      ||......|..|             :.|..|.:||:.:|.:::..|
Mouse   189 --------EAGLE------DLVSVLTCVGGCQIAVNQSWVFINFLLFLIPTLVMMTVYSKIFLIA 239

  Fly   323 QKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVF 387
            ::..::|       |...||..::....|::..|               .:.|||.|:|:.:..|
Mouse   240 KQQAQNI-------EKMSKQTARASESYKDRVAK---------------RERKAAKTLGIAVAAF 282

  Fly   388 LICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            |:.|:|:|..:|..||.........::||.|:.|.|||.||:||:.|...||.|.|.|:|
Mouse   283 LLSWLPYFIDSIIDAFLGFITPTYVYEILVWIAYYNSAMNPLIYAFFYPWFRKAIKLIVT 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	94/313 (30%)
		TM helix 1	130..156	CDD:320193	7/14 (50%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	12/29 (41%)
		TM helix 4	243..265	CDD:320193	7/21 (33%)
		TM helix 5	292..321	CDD:320193	7/41 (17%)
		TM helix 6	371..401	CDD:320193	11/29 (38%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
Taar7a	NP_001010829.1	7tm_GPCRs	49..337	CDD:475119	94/313 (30%)
		TM helix 1	50..74	CDD:320439	7/13 (54%)
		TM helix 2	83..105	CDD:320439	11/21 (52%)
		TM helix 3	121..143	CDD:320439	6/21 (29%)
		TM helix 4	166..182	CDD:320439	6/15 (40%)
		TM helix 5	210..233	CDD:320439	4/22 (18%)
		TM helix 6	272..294	CDD:320439	8/21 (38%)
		TM helix 7	305..330	CDD:320439	11/24 (46%)