DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and DRD1

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_000785.1	Gene:	DRD1 / 1812	HGNCID:	3020	Length:	446	Species:	Homo sapiens

Alignment Length:	483	Identity:	167/483 - (34%)
Similarity:	240/483 - (49%)	Gaps:	82/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LLTNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCL 151
            |.|:..|||.|           ..|.|..|.           ::...|||:||..::.||.|||.
Human     4 LNTSAMDGTGL-----------VVERDFSVR-----------ILTACFLSLLILSTLLGNTLVCA 46

  Fly   152 AIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTAS 215
            |:...|.|| ::.|.|:.|||::||.||.|||.:..|.::.|:|.||: ||:.|||||:||||||
Human    47 AVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMCSTAS 110

  Fly   216 ILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIH--RPDQPLIFE 278
            |||||.||:|||..|..|.||.|.:|.:.|.|.|:..|.|:..:||:|:.|..|  :|..|  .:
Human   111 ILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSP--SD 173

  Fly   279 DN----GKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVA 339
            .|    .:....|...|:.|||:.||.||||.|..:||..|.|:|..|||.::.|.|:.|....|
Human   174 GNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHA 238

  Fly   340 EK-QRYKSIRRPK--NQPKKFKVRNLHTHSSPYHVS---DHKAAVTVGVIMGVFLICWVPFFCVN 398
            :. |......:|.  :||:           |.:.:|   :.|...|:.||||||:.||:|||.:|
Human   239 KNCQTTTGNGKPVECSQPE-----------SSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILN 292

  Fly   399 ITAAFCKT------CIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQD 457
            ....||.:      ||...||.:..|.|::||:.|||||: ||.:||.||..:|.... .|.|
Human   293 CILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGCYR-LCPA-- 353

  Fly   458 VGNIHPRNSDRFITDYAAKNVVVMNSGRS--SAELEQVSAIXPKCCLNLTGGGATWLPCGCGGLR 520
                         |:.|.:.|.:.|:|.:  |:..|...:|..:|.|      ...:|...|...
Human   354 -------------TNNAIETVSINNNGAAMFSSHHEPRGSISKECNL------VYLIPHAVGSSE 399

  Fly   521 VDDDDDGALTTRYVPXDSVTAATATIVE 548
            ....::.|...|  |.:.::.|.:.|::
Human   400 DLKKEEAAGIAR--PLEKLSPALSVILD 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	68/132 (52%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	125/304 (41%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	136/343 (40%)
		TM helix 1	26..50	CDD:320443	11/23 (48%)
		TM helix 2	60..82	CDD:320443	12/21 (57%)
		TM helix 3	97..119	CDD:320443	17/21 (81%)
		TM helix 4	142..158	CDD:320443	6/15 (40%)
		TM helix 5	192..215	CDD:320443	12/22 (55%)
		TM helix 6	271..293	CDD:320443	12/21 (57%)
		TM helix 7	310..335	CDD:320443	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2628
eggNOG	1	0.900	-	-		E33208_3B9BF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3358
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm40833
orthoMCL	1	0.900	-	-		OOG6_107579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4063
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760