Protein Alignment Dop1R1 and ser-4

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_497452.1
• Gene: ser-4 / 175322
• WormBaseID: WBGene00004779
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 402
• Identity: 122/402 - (30%)
• Similarity: 175/402 - (43%)
• Gaps: 83/402 - (20%)

  Fly   118 EEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLA-SLAIADLFVASLV 181
            |.|    ||..|::...|.|||.....||:.|.|||..||.||.....:|. |||:|||.|..:|
 Worm    45 ERP----LVQTVILASVLLVLILSCFIGNLFVILAIIMERDLRGRPQYYLIFSLAVADLLVGMIV 105

  Fly   182 MTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAV 246
            ........:.|.|..|...||.|::.||:..|||||:|.||::|||..|.| :.|.:..|.:...
 Worm   106 TPLGAWFTVTGTWNLGVVVCDFWISVDVLVCTASILHLVAIALDRYWSITD-ICYVQNRTPKRIT 169

  Fly   247 ITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVM 311
            :.:|.||..:..:|..|.:   ...|:.  |.|...|...|.:....:|.|.|:..:||.|.:.:
 Worm   170 LMLAVIWFTSLLISLAPFA---GWKDEG--FSDRVLKSHVCLISQQISYQVFSTATAFYIPLIAI 229

  Fly   312 IGIYCRLYCYAQKHVK---SIKAVTR--PGEVAEKQRY---KSIRRP------------------ 350
            |.:|.::...|:|..|   ..:.|.|  |..:.||:..   ||.:.|
 Worm   230 ICVYWKIMRAAKKRFKRERDRRTVIRPPPDAIDEKKAMMPKKSKKCPLPPAVVISDIQANGGTGG 294

  Fly   351 -----KNQPK----------------------------KFKVRNLHTHSSPYHVS---------- 372
                 ||.|:                            :.|:...:..|.|..|.
 Worm   295 KTNSIKNPPRHNESSSSASEEERTMTQTNHAPGDVTTQETKIDEENGRSKPGIVKRRRRTKESNE 359

  Fly   373 ---DHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIF 434
               :.||..|:.:|.|.|:.||.|||.|:|....|...|.....::..||||.|||.|||||::|
 Worm   360 MKRERKAWRTLAIITGTFVACWTPFFLVSIYRPICGCQISPVLEQVTLWLGYLNSALNPIIYTVF 424

  Fly   435 NKEFRDAFKRIL 446
            :::||.|||||:
 Worm   425 SQDFRAAFKRII 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	112/384 (29%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	9/26 (35%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	8/28 (29%)
		TM helix 6	371..401	CDD:320193	14/42 (33%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
ser-4	NP_497452.1	7tmA_5-HT1A_invertebrates	52..432	CDD:320454	113/385 (29%)
		TM helix 1	53..79	CDD:320454	10/25 (40%)
		TM helix 2	87..113	CDD:320454	9/25 (36%)
		TM helix 3	125..155	CDD:320454	16/29 (55%)
		TM helix 4	166..188	CDD:320454	5/21 (24%)
		TM helix 5	210..239	CDD:320454	8/28 (29%)
		TM helix 6	361..391	CDD:320454	13/29 (45%)
		TM helix 7	400..425	CDD:320454	12/24 (50%)