DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dop1R1 and Htr6

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001364025.1	Gene:	Htr6 / 15565	MGIID:	1196627	Length:	440	Species:	Mus musculus

Alignment Length:	327	Identity:	120/327 - (36%)
Similarity:	170/327 - (51%)	Gaps:	29/327 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 VGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWI 195
            |...|.|:|.|:.|.|.|:...|.|:.:||...|.||.||..:||.|..:||..|.:|.|.|.|:
Mouse    29 VAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWV 93

  Fly   196 FGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVS 260
            .....|..|.||||||.:|||||||.||:|||:.|..||||...:|...|:..|...|.|||..|
Mouse    94 LARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALAS 158

  Fly   261 FVPISLGIHR--------PDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCR 317
            |:|:.||.|.        |.|             |.|..:..|.:|:|.::|:.|...:...|||
Mouse   159 FLPLLLGWHELGKARTSAPGQ-------------CRLLASLPYVLVASGVTFFLPSGAICFTYCR 210

  Fly   318 LYCYAQKHVKSIKAVTRPGEVAEKQRYKSI---RRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVT 379
            :...|:|....:.::| .|.....|..:::   |.|:...:....|.|.|..|...:   ||::|
Mouse   211 ILLAARKQAVQVASLT-TGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKAL---KASLT 271

  Fly   380 VGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKR 444
            :|:::.:|.:.|:|||..:|..|.| .||....|.:||||||.||..|||||.:|.::|:.|..|
Mouse   272 LGILLSMFFVTWLPFFVASIAQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGR 335

  Fly   445 IL 446
            .:
Mouse   336 FV 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	61/131 (47%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	108/296 (36%)
Htr6	NP_001364025.1	7tmA_5-HT6	29..333	CDD:320182	118/321 (37%)
		TM helix 1	29..53	CDD:320182	9/23 (39%)
		TM helix 2	62..84	CDD:320182	10/21 (48%)
		TM helix 3	100..122	CDD:320182	15/21 (71%)
		TM helix 4	145..161	CDD:320182	7/15 (47%)
		TM helix 5	186..209	CDD:320182	5/22 (23%)
		TM helix 6	269..291	CDD:320182	7/21 (33%)
		TM helix 7	301..326	CDD:320182	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010