Protein Alignment Dop1R1 and Htr1d

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_032335.2
• Gene: Htr1d / 15552
• MGIID: 96276
• Length: 374
• Species: Mus musculus
• Alignment Length: 380
• Identity: 115/380 - (30%)
• Similarity: 175/380 - (46%)
• Gaps: 84/380 - (22%)

  Fly   119 EPEPLSL--VSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLV 181
            :||.|..  :|:|||   |||:...:|..|..|...|...:.|....|..:.|||..||.|:.||
Mouse    27 DPEVLQALRISLVVV---LSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILV 88

  Fly   182 MTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAV 246
            |..:........|.||...||.||:.|:.|.|||||:||.|::|||..|.|.|.|.:..|...|.
Mouse    89 MPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAA 153

  Fly   247 ITIAAIWLLAAFVSFVPI---SLGIHRPDQPLIFEDNGKKYPTCALDLTP-TYAVVSSCISFYFP 307
            ..|||:|:::..:|..|:   ....|            ::...|.::.:. :|.:.|:|.:||.|
Mouse   154 AMIAAVWIISICISIPPLFWRQATAH------------EEMSDCLVNTSQISYTIYSTCGAFYIP 206

  Fly   308 CVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNL---------- 362
            .:::|.:|.|:|..|:..:                    :..|....|:|....|
Mouse   207 SILLIILYGRIYVAARSRI--------------------LNPPSLYGKRFTTAQLITGSAGSSLC 251

  Fly   363 ---------HTHS--SPYHVS--------------------DHKAAVTVGVIMGVFLICWVPFFC 396
                     |||:  ||...:                    :.||..|:|:|:|.|:|||:|||.
Mouse   252 SLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFV 316

  Fly   397 VNITAAFCK-TC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMR 449
            |::....|: :| |....|...|||||.||..||:||::||::||.||::::..|
Mouse   317 VSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFR 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	107/358 (30%)
		TM helix 1	130..156	CDD:320193	9/25 (36%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	7/24 (29%)
		TM helix 5	292..321	CDD:320193	10/29 (34%)
		TM helix 6	371..401	CDD:320193	14/49 (29%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Htr1d	NP_032335.2	7tm_GPCRs	32..364	CDD:475119	109/366 (30%)
		TM helix 1	38..62	CDD:320455	10/26 (38%)
		TM helix 2	71..93	CDD:320455	10/21 (48%)
		TM helix 3	109..131	CDD:320455	13/21 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	5/15 (33%)
		TM helix 5	192..215	CDD:320455	7/22 (32%)
		TM helix 6	297..319	CDD:320455	12/21 (57%)
		TM helix 7	332..357	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		2/3 (67%)