Protein Alignment Dop1R1 and Htr1b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_034612.1
• Gene: Htr1b / 15551
• MGIID: 96274
• Length: 386
• Species: Mus musculus
• Alignment Length: 398
• Identity: 111/398 - (27%)
• Similarity: 183/398 - (45%)
• Gaps: 67/398 - (16%)

  Fly    94 GTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERS 158
            |..||:..:..|.......|:|.  .|..:.||::      |:::...:...|..|...:|..|.
Mouse    19 GVPLTNLSHNCSADGYIYQDSIA--LPWKVLLVAL------LALITLATTLSNAFVIATVYRTRK 75

  Fly   159 LRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAIS 223
            |....|..:||||:.||.|:.|||..:.:..:.|.|..|...||.|::.|:.|.||||::||.|:
Mouse    76 LHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIA 140

  Fly   224 MDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCA 288
            :|||..|.|.:.|....|.:.|.|.|..:|:.:..:|..|......:.::.::         .|.
Mouse   141 LDRYWAITDAVEYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEML---------DCF 196

  Fly   289 LDLTPT-YAVVSSCISFYFPCVVMIGIYCRLYCYAQKHV------KSIKAVTR-------PGEVA 339
            ::.... |.|.|:..:||.|.:::|.:|.|:|..|:..:      |:.|.:||       ||..:
Mouse   197 VNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTS 261

  Fly   340 EKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVS--------------------DHKAAVTVGVIM 384
            ......|  |..:.|.:        ..||.:|:                    :.||..|:|:|:
Mouse   262 SVTSINS--RAPDVPSE--------SGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIIL 316

  Fly   385 GVFLICWVPFFCVNITAAFCK-TC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            |.|::||:|||.:::....|| .| .....|....||||.||..|||||::.|::|:.||.:::.
Mouse   317 GAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 381

  Fly   448 MRNPWCCA 455
            .:    ||
Mouse   382 FK----CA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	98/347 (28%)
		TM helix 1	130..156	CDD:320193	4/25 (16%)
		TM helix 2	163..189	CDD:320193	11/25 (44%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	10/29 (34%)
		TM helix 6	371..401	CDD:320193	13/49 (27%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Htr1b	NP_034612.1	7tmA_5-HT1B_1D	42..376	CDD:320455	101/358 (28%)
		TM helix 1	47..73	CDD:320455	6/31 (19%)
		TM helix 2	80..106	CDD:320455	11/25 (44%)
		TM helix 3	118..148	CDD:320455	15/29 (52%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	142..144		1/1 (100%)
		TM helix 4	160..183	CDD:320455	6/22 (27%)
		TM helix 5	201..230	CDD:320455	10/28 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	255..278		5/32 (16%)
		TM helix 6	303..333	CDD:320455	12/29 (41%)
		TM helix 7	344..369	CDD:320455	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	361..365		3/3 (100%)