Protein Alignment Dop1R1 and Htr1a

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 392
• Identity: 120/392 - (30%)
• Similarity: 185/392 - (47%)
• Gaps: 87/392 - (22%)

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            |:..:.|..|||.:|.||..|..||..||||:.:.|..:.|||:.||.|:.||:..|.:..:|..
Mouse    37 VITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK 101

  Fly   194 WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAF 258
            |..|...||.::|.||:|.|:|||:||||::|||..|.||:.|....|.|.|...|:..||:...
Mouse   102 WTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFL 166

  Fly   259 VSFVPISLGIHRPDQPLIFEDNGKKYPT-CALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYA 322
            :| :|..||...|:.        :..|. |.:.....|.:.|:..:||.|.::|:.:|.|::..|
Mouse   167 IS-IPPMLGWRTPED--------RSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAA 222

  Fly   323 QKHV-KSIKAVTRPG-------------------------------------------------- 336
            :..: |::|.|.:.|
Mouse   223 RFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDD 287

  Fly   337 ---EVAEKQRYKS----IRRPKNQ------PKKFKVRNLHTHSSPYHVS---DHKAAVTVGVIMG 385
               ||.|..|..:    :..|...      |...:.:|..|..:...::   :.|...|:|:|||
Mouse   288 ATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMG 352

  Fly   386 VFLICWVPFFCVNITAAFCK-TC-----IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKR 444
            .|::||:|||.|.:...||: :|     :|.    |:.|||||||..||:||:.|||:|::|||:
Mouse   353 TFILCWLPFFIVALVLPFCESSCHMPELLGA----IINWLGYSNSLLNPVIYAYFNKDFQNAFKK 413

  Fly   445 IL 446
            |:
Mouse   414 II 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	115/385 (30%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	7/21 (33%)
		TM helix 5	292..321	CDD:320193	8/28 (29%)
		TM helix 6	371..401	CDD:320193	13/32 (41%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Htr1a	NP_032334.2	7tmA_5-HT1A_vertebrates	37..411	CDD:320453	116/386 (30%)
		TM helix 1	38..64	CDD:320453	10/25 (40%)
		TM helix 2	71..97	CDD:320453	10/25 (40%)
		TM helix 3	109..139	CDD:320453	17/29 (59%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	7/22 (32%)
		TM helix 5	192..221	CDD:320453	8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		1/30 (3%)
		TM helix 6	338..368	CDD:320453	13/29 (45%)
		TM helix 7	379..404	CDD:320453	13/28 (46%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)