DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and ADRB3

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_000016.1	Gene:	ADRB3 / 155	HGNCID:	288	Length:	408	Species:	Homo sapiens

Alignment Length:	402	Identity:	132/402 - (32%)
Similarity:	203/402 - (50%)	Gaps:	55/402 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 VVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYW 194
            :.|..|::.:..:|.||:||.:||.....|:.:.|:|:.|||.|||.:..||:..|....|.|:|
Human    39 LAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHW 103

  Fly   195 IFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFV 259
            ..||..|:.|.:.||:|.||||..|||:::|||:.:.:|||||..||:|.|...:..:|:::|.|
Human   104 PLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAV 168

  Fly   260 SFVPI-----SLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLY 319
            ||.||     .:|.....|..  ..|.:   .||......|.::||.:|||.|.:||:.:|.|::
Human   169 SFAPIMSQWWRVGADAEAQRC--HSNPR---CCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVF 228

  Fly   320 CYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHV------------- 371
            ..|.:.::.::     ||:.   |:.....|....:......:.|.:.|..|
Human   229 VVATRQLRLLR-----GELG---RFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL 285

  Fly   372 SDHKAAVTVGVIMGVFLICWVPFFCVNITAAF-CKTCIGGQTFKILTWLGYSNSAFNPIIYSIFN 435
            .:|:|..|:|:|||.|.:||:|||..|:..|. ..:.:.|..|..|.||||:||||||:|| ..:
Human   286 REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY-CRS 349

  Fly   436 KEFRDAFKRILTMRNPWC-CAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSAELEQVSAIXPK 499
            .:||.||:|:|      | |.:   .:.|.       ..||....:..||..:|   :.|.. |:
Human   350 PDFRSAFRRLL------CRCGR---RLPPE-------PCAAARPALFPSGVPAA---RSSPAQPR 395

  Fly   500 CCLNLTGGGATW 511
            .|..|  .||:|
Human   396 LCQRL--DGASW 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	56/136 (41%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	106/304 (35%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:333717	111/318 (35%)
		TM helix 2	73..95	CDD:320095	10/21 (48%)
		TM helix 3	111..133	CDD:320095	11/21 (52%)
		TM helix 4	156..172	CDD:320095	5/15 (33%)
		TM helix 5	202..225	CDD:320095	9/22 (41%)
		TM helix 6	288..313	CDD:320095	13/24 (54%)
		TM helix 7	325..350	CDD:320095	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910