Protein Alignment Dop1R1 and Drd3

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_006521840.1
• Gene: Drd3 / 13490
• MGIID: 94925
• Length: 478
• Species: Mus musculus
• Alignment Length: 485
• Identity: 138/485 - (28%)
• Similarity: 203/485 - (41%)
• Gaps: 155/485 - (31%)

  Fly    92 YDGTTLTSFYNESSWTNA------SEMDTIVGEE-------PEPLSLVSIVVVGIFLSVLIFLSV 143
            :.|..|.|  |.|.|..|      |.:::..|.|       ..|.:..::....:.|:::.
Mouse    19 FSGNILES--NSSVWAMAPLSQISSHINSTCGAENSTGVNRARPHAYYALSYCALILAIIF---- 77

  Fly   144 AGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLL-GYWIFGAQFCDTWVAF 207
             ||.|||.|:..||:|:...|..:.|||:|||.||:|||.:....::. |.|.|....||.:|..
Mouse    78 -GNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTL 141

  Fly   208 DVMCSTASILNLCAISMDRYIHIKDPLRY----GRWVTRRVAVITIAAIWLLAAFVSFVPISLGI 268
            |||..|||||||||||:|||..:..|:.|    |:...||||:: |.|:|:||..|| .|:..|.
Mouse   142 DVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALM-ITAVWVLAFAVS-CPLLFGF 204

  Fly   269 HRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLY-------------- 319
            :....|.|          |::. .|.:.:.||.:|||.|..|.:.:|.|:|
Mouse   205 NTTGDPSI----------CSIS-NPDFVIYSSVVSFYVPFGVTVLVYARIYMVLRQRRRKRILTR 258

  Fly   320 -----------------C------------------------------YAQK-------HVKSIK 330
                             |                              |.||       |::.:.
Mouse   259 QNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKPYPQKCQDPLLSHLQPLS 323

  Fly   331 AVTRPGEV-AEKQRYKSI--------------------RRPKNQ------PK------------- 355
                ||:. .|.:||.||                    .|.:|.      ||
Mouse   324 ----PGQTHGELKRYYSICQDTALRHPNFEGGGGMSQVERTRNSLSPTMAPKLSLEVRKLSNGRL 384

  Fly   356 --KFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-IGGQTFKILT 417
              ..|:..|.....|  :.:.||...|.:::|.|::||:|||..::....|:.| :..:.::..|
Mouse   385 STSLKLGPLQPRGVP--LREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATT 447

  Fly   418 WLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            ||||.|||.||:||:.||.|||.||.:||:
Mouse   448 WLGYVNSALNPVIYTTFNIEFRKAFLKILS 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	123/427 (29%)
		TM helix 1	130..156	CDD:320193	7/25 (28%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	11/21 (52%)
		TM helix 5	292..321	CDD:320193	12/89 (13%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
Drd3	XP_006521840.1	7tmA_D3_dopamine_R	62..472	CDD:320436	123/433 (28%)
		TM helix 1	63..89	CDD:320436	7/30 (23%)
		TM helix 2	96..119	CDD:320436	12/22 (55%)
		TM helix 3	135..165	CDD:320436	20/29 (69%)
		TM helix 4	182..200	CDD:320436	9/19 (47%)
		TM helix 5	217..242	CDD:320436	9/24 (38%)
		TM helix 6	400..430	CDD:320436	10/29 (34%)
		TM helix 7	440..465	CDD:320436	12/24 (50%)