Protein Alignment Dop1R1 and Drd2

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_034207.2
• Gene: Drd2 / 13489
• MGIID: 94924
• Length: 444
• Species: Mus musculus
• Alignment Length: 458
• Identity: 133/458 - (29%)
• Similarity: 202/458 - (44%)
• Gaps: 132/458 - (28%)

  Fly    99 SFYNE----SSWT---NASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTE 156
            |:|::    .:|:   |.||     |:...|    ......:.|::|||:.|.||:|||:|:..|
Mouse     7 SWYDDDLERQNWSRPFNGSE-----GKPDRP----HYNYYAMLLTLLIFIIVFGNVLVCMAVSRE 62

  Fly   157 RSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCA 221
            ::|:...|..:.|||:|||.||:|||.:....:::|.|.|....||.:|..|||..|||||||||
Mouse    63 KALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCA 127

  Fly   222 ISMDRYIHIKDPLRYG-RWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYP 285
            ||:|||..:..|:.|. |:.::|...:.||.:|:|:..:| .|:..|::..||           .
Mouse   128 ISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTIS-CPLLFGLNNTDQ-----------N 180

  Fly   286 TCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKA------------------V 332
            .|.: ..|.:.|.||.:|||.|.:|.:.:|.::|...:|..|.:..                  .
Mouse   181 ECII-ANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNC 244

  Fly   333 TRPGEV---------------------------------------AEKQRYKSIRRPKNQ----- 353
            |.|.::                                       .|:.||..|....:|
Mouse   245 THPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPD 309

  Fly   354 ---------------PKK--------------FKVR---NLHTHSSPYHVS--------DHKAAV 378
                           |:|              |:::   |..|.:|...:|        :.||..
Mouse   310 PSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQ 374

  Fly   379 TVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFK 443
            .:.:::|||:|||:|||..:|....|...|....:...|||||.|||.|||||:.||.|||.||.
Mouse   375 MLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFM 439

  Fly   444 RIL 446
            :||
Mouse   440 KIL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	121/414 (29%)
		TM helix 1	130..156	CDD:320193	11/25 (44%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	20/29 (69%)
		TM helix 4	243..265	CDD:320193	7/21 (33%)
		TM helix 5	292..321	CDD:320193	11/28 (39%)
		TM helix 6	371..401	CDD:320193	13/37 (35%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)
Drd2	NP_034207.2	7tmA_D2_dopamine_R	35..438	CDD:320435	121/415 (29%)
		TM helix 1	36..62	CDD:320435	11/25 (44%)
		TM helix 2	69..92	CDD:320435	12/22 (55%)
		TM helix 3	107..137	CDD:320435	20/29 (69%)
		TM helix 4	152..170	CDD:320435	5/18 (28%)
		TM helix 5	186..211	CDD:320435	10/24 (42%)
		Interaction with PPP1R9B. /evidence=ECO:0000250	211..374		19/162 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..329		7/46 (15%)
		TM helix 6	367..397	CDD:320435	12/29 (41%)
		TM helix 7	406..431	CDD:320435	13/24 (54%)