DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and Drd1

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001278730.1	Gene:	Drd1 / 13488	MGIID:	99578	Length:	446	Species:	Mus musculus

Alignment Length:	409	Identity:	148/409 - (36%)
Similarity:	208/409 - (50%)	Gaps:	79/409 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLG 192
            ::...|||:||..::.||.|||.|:...|.|| ::.|.|:.|||::||.||.|||.:..|.::.|
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   193 YWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAA 257
            :|.||: ||:.|||||:|||||||||||.||:|||..|..|.:|.|.:|.:.|.|.|:..|.|:.
Mouse    88 FWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSV 151

  Fly   258 FVSFVPISLGIH--RPDQPL---------IFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVM 311
            .:||:|:.|..|  :|..||         ..:||      |...|:.|||:.||.||||.|..:|
Mouse   152 LISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDN------CDTRLSRTYAISSSLISFYIPVAIM 210

  Fly   312 IGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHT---HSSPYHVS- 372
            |..|..:|..|||.::.|.|:.|....|                    :|..|   :.:|...|
Mouse   211 IVTYTSIYRIAQKQIRRISALERAAVHA--------------------KNCQTTTGNGNPVECSQ 255

  Fly   373 -----------DHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKT------CIGGQTFKILTWLG 420
                       :.|...|:.||||||:.||:|||..|....||.:      ||...||.:..|.|
Mouse   256 SESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFG 320

  Fly   421 YSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSG- 484
            ::||:.|||||: ||.:|:.||..:|.      |.:    :.|      .|:.|.:.|.:.|:|
Mouse   321 WANSSLNPIIYA-FNADFQKAFSTLLG------CYR----LCP------TTNNAIETVSINNNGA 368

  Fly   485 -RSSAELEQVSAIXPKCCL 502
             ..|:..|...:| ..|.|
Mouse   369 VMFSSHHEPRGSISKDCNL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	67/132 (51%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	123/318 (39%)
Drd1	NP_001278730.1	7tm_1	39..331	CDD:278431	123/318 (39%)
Drd1	NP_001278730.1	7tm_4	40..>157	CDD:304433	60/117 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2525
eggNOG	1	0.900	-	-		E33208_3B9BF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3277
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm42907
orthoMCL	1	0.900	-	-		OOG6_107579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4063
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760