Protein Alignment Dop1R1 and Drd1

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 409
• Identity: 148/409 - (36%)
• Similarity: 208/409 - (50%)
• Gaps: 79/409 - (19%)

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLG 192
            ::...|||:||..::.||.|||.|:...|.|| ::.|.|:.|||::||.||.|||.:..|.::.|
Mouse    23 ILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG 87

  Fly   193 YWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAA 257
            :|.||: ||:.|||||:|||||||||||.||:|||..|..|.:|.|.:|.:.|.|.|:..|.|:.
Mouse    88 FWPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSV 151

  Fly   258 FVSFVPISLGIH--RPDQPL---------IFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVM 311
            .:||:|:.|..|  :|..||         ..:||      |...|:.|||:.||.||||.|..:|
Mouse   152 LISFIPVQLSWHKAKPTWPLDGNFTSLEDAEDDN------CDTRLSRTYAISSSLISFYIPVAIM 210

  Fly   312 IGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHT---HSSPYHVS- 372
            |..|..:|..|||.::.|.|:.|....|                    :|..|   :.:|...|
Mouse   211 IVTYTSIYRIAQKQIRRISALERAAVHA--------------------KNCQTTTGNGNPVECSQ 255

  Fly   373 -----------DHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKT------CIGGQTFKILTWLG 420
                       :.|...|:.||||||:.||:|||..|....||.:      ||...||.:..|.|
Mouse   256 SESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFG 320

  Fly   421 YSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSG- 484
            ::||:.|||||: ||.:|:.||..:|.      |.:    :.|      .|:.|.:.|.:.|:|
Mouse   321 WANSSLNPIIYA-FNADFQKAFSTLLG------CYR----LCP------TTNNAIETVSINNNGA 368

  Fly   485 -RSSAELEQVSAIXPKCCL 502
             ..|:..|...:|...|.|
Mouse   369 VMFSSHHEPRGSISKDCNL 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	133/344 (39%)
		TM helix 1	130..156	CDD:320193	11/25 (44%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	22/29 (76%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	14/28 (50%)
		TM helix 6	371..401	CDD:320193	15/41 (37%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	133/345 (39%)
		TM helix 1	25..49	CDD:410628	11/23 (48%)
		TM helix 2	59..81	CDD:410628	12/21 (57%)
		TM helix 3	96..118	CDD:410628	17/21 (81%)
		TM helix 4	141..157	CDD:410628	6/15 (40%)
		TM helix 5	192..215	CDD:410628	12/22 (55%)
		TM helix 6	271..293	CDD:410628	12/21 (57%)
		TM helix 7	310..335	CDD:410628	12/25 (48%)