Protein Alignment Dop1R1 and TAAR1

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_612200.1
• Gene: TAAR1 / 134864
• HGNCID: 17734
• Length: 339
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 103/366 - (28%)
• Similarity: 165/366 - (45%)
• Gaps: 50/366 - (13%)

  Fly   103 ESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFL 167
            :::|:|...           .||.|::|      ::|..::.||::|.::|...:.|....|..:
Human    15 KNNWSNDVR-----------ASLYSLMV------LIILTTLVGNLIVIVSISHFKQLHTPTNWLI 62

  Fly   168 ASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKD 232
            .|:|..|..:..|||.::.|......|.||..||....:.|:|.|:|||.:|..||:|||..:.|
Human    63 HSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCD 127

  Fly   233 PLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAV 297
            ||||...:...|..:.|...|.:.|..:|..|.|.::......|:..:......|::..:....|
Human   128 PLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGV 192

  Fly   298 VSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNL 362
            ::...|||.|..:|:.:|.|:|..|::..:.|....:..::..:.        ||...:.|.|
Human   193 LTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEM--------KNGISQSKER-- 247

  Fly   363 HTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFN 427
                        ||..|:|::||||||||.|||...:...|....|......:|.|.||.||.||
Human   248 ------------KAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 300

  Fly   428 PIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDR 468
            |::|:.|...||.|.|.:|           .|.|..::|.|
Human   301 PMVYAFFYPWFRKALKMML-----------FGKIFQKDSSR 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	91/311 (29%)
		TM helix 1	130..156	CDD:320193	6/25 (24%)
		TM helix 2	163..189	CDD:320193	8/25 (32%)
		TM helix 3	201..231	CDD:320193	13/29 (45%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	9/28 (32%)
		TM helix 6	371..401	CDD:320193	15/29 (52%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
TAAR1	NP_612200.1	7tmA_TAAR1	26..315	CDD:320438	93/316 (29%)
		TM helix 1	26..51	CDD:320438	8/30 (27%)
		TM helix 2	58..84	CDD:320438	8/25 (32%)
		TM helix 3	96..126	CDD:320438	13/29 (45%)
		TM helix 4	138..161	CDD:320438	6/22 (27%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465	175..186		1/10 (10%)
		TM helix 5	187..216	CDD:320438	9/28 (32%)
		TM helix 6	244..274	CDD:320438	17/43 (40%)
		TM helix 7	283..308	CDD:320438	10/24 (42%)