Protein Alignment Dop1R1 and TAAR9

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 361
• Identity: 101/361 - (27%)
• Similarity: 150/361 - (41%)
• Gaps: 61/361 - (16%)

  Fly   103 ESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIF---LSVAGNILVCLAIYTERSLRRIGN 164
            |..:.|.:|........|.|.|        |..:||.|   |:..||:||.:||...:.|....|
Human    12 ELCYKNVNESCIKTPYSPGPRS--------ILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTN 68

  Fly   165 LFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIH 229
            ..:||||.||..|...||.|:.|..:...|.||..:|.....||.....||:.:||.||:||||.
Human    69 FLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIA 133

  Fly   230 IKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPT 294
            :.|||.|....|..|:.|.|...|..:...||.....|.:         :.|.:      :|...
Human   134 VTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGAN---------EEGIE------ELVVA 183

  Fly   295 YAVVSSC-------------ISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKS 346
            ...|..|             :.|:.|.|.|:.||.:::..|:...:.|::.....: :..:.||.
Human   184 LTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQ-SSSESYKE 247

  Fly   347 IRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQ 411
             |..|.                    :.|||.|:|:.|..||:.|:|:....:..|:........
Human   248 -RVAKR--------------------ERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPY 291

  Fly   412 TFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILT 447
            .::||.|..|.|||.||:||:.|.:.|..|.|.|::
Human   292 VYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	92/327 (28%)
		TM helix 1	130..156	CDD:320193	11/28 (39%)
		TM helix 2	163..189	CDD:320193	12/25 (48%)
		TM helix 3	201..231	CDD:320193	13/29 (45%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	8/41 (20%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	93/333 (28%)
		TM helix 1	34..60	CDD:320439	11/25 (44%)
		TM helix 2	67..93	CDD:320439	12/25 (48%)
		TM helix 3	105..135	CDD:320439	13/29 (45%)
		TM helix 4	147..170	CDD:320439	6/22 (27%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		2/18 (11%)
		TM helix 5	194..223	CDD:320439	6/28 (21%)
		TM helix 6	251..281	CDD:320439	11/49 (22%)
		TM helix 7	290..315	CDD:320439	11/24 (46%)