Protein Alignment Dop1R1 and Dop2R

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_061499915.1
• Gene: Dop2R / 1274598
• VectorBaseID: AGAMI1_010373
• Length: 659
• Species: Anopheles gambiae
• Alignment Length: 636
• Identity: 160/636 - (25%)
• Similarity: 226/636 - (35%)
• Gaps: 237/636 - (37%)

  Fly    19 AATVATSTTSSISSSTTIINTSSATTIGGNHTS---GSTGFSTNSTLLDADHLPLQLTTAKVDLD 80
            |.||:.||.     :|.:.|.||  .:..|.|.   .......|.:|    ..|:..:|......
Mosquito    50 APTVSVSTV-----ATMLSNVSS--NVASNDTDQYYADDPAPYNDSL----ESPISDSTDSRGSI 103

  Fly    81 IEI---DIQLL---TNGYDGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLI 139
            .|:   ||..:   .||..|...|......|.:|.    |.:|    |..........:.|.:..
Mosquito   104 FELLAEDIGSIFYNANGTFGNDTTGLAVNCSLSNT----TCIG----PTEAKEYHYWCLILVLFP 160

  Fly   140 FLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTW 204
            .|::.||:||.||:..||:|:.:.|.|:.|||||||.||.:||.||....:.|.|......||.:
Mosquito   161 ILTLFGNVLVILAVCRERTLQTVTNYFIVSLAIADLLVAVVVMPFAVYVLVNGAWTLPNFACDFY 225

  Fly   205 VAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIH 269
            :|.||:|||:||.||.|||:||||.:..|::|.:....|...:||..:|.::|.:. .||.||::
Mosquito   226 IAMDVICSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIG-SPIVLGLN 289

  Fly   270 RPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTR 334
            ....         :.|...:.....:.|.||..|||.||::|:.:|..::...:...|..:|..:
Mosquito   290 NTQD---------RSPDLCVFYNTDFIVYSSLTSFYIPCIIMVFLYWNIFKALRTRAKKQRAARK 345

  Fly   335 P--------GEV----------AEKQRYKSIR----------RPKN------------------- 352
            |        |.:          ||.|...|.|          ||.|
Mosquito   346 PHLSEITAGGSIIENIAQTKRLAETQLDGSTRSGSKILPDEERPTNTASGSNEEDDENAGSPDID 410

  Fly   353 ----------------------------------------------------------------- 352
                                                                             
Mosquito   411 DCHVIVNDKSTEFMLATVVEEAGNKSFSTSTFSVVAQIATTQQVPSDPNGNHDSGYAPSSIADAL 475

  Fly   353 -----QPKKFKV--------------------------------------------RN---LHTH 365
                 .|:...|                                            ||   |.|:
Mosquito   476 AVNATPPESLNVTATVIVNKSATIRSRNGSPRKEASVTLKPLSLVRCGVQQALTLNRNDSTLSTN 540

  Fly   366 S----------------SPYHVS--------------DHKAAVTVGVIMGVFLICWVPFFCVNIT 400
            |                :.|.|:              :.||..|:.:::||||.||||||..||.
Mosquito   541 SRDSSRKDKKNTQASRFTIYKVNKASKKKREKSSAKKERKATKTLAIVLGVFLFCWVPFFTCNIM 605

  Fly   401 AAFC----KTCIGGQT-FKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
            .|.|    |.|..|.| |.:.|||||.||..||:||:|||.|||.|||:|:
Mosquito   606 DAMCAKLDKDCRPGVTIFNLTTWLGYMNSFVNPVIYTIFNPEFRKAFKKIM 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	129/510 (25%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	15/25 (60%)
		TM helix 3	201..231	CDD:320193	19/29 (66%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	10/28 (36%)
		TM helix 6	371..401	CDD:320193	16/43 (37%)
		TM helix 7	410..435	CDD:320193	15/25 (60%)
Dop2R	XP_061499915.1	None