DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and Adrb1

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_031445.2	Gene:	Adrb1 / 11554	MGIID:	87937	Length:	466	Species:	Mus musculus

Alignment Length:	437	Identity:	143/437 - (32%)
Similarity:	205/437 - (46%)	Gaps:	80/437 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 EEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVM 182
            |...|||......:|:.|::::.|.|.||:||.:||.....|:.:.|||:.|||.|||.:..||:
Mouse    48 EGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVV 112

  Fly   183 TFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVI 247
            .|.....:.|.|.:|:.||:.|.:.||:|.||||..||.|::|||:.|..|.||...:||..|..
Mouse   113 PFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARA 177

  Fly   248 TIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKY---PTCALDLT-PTYAVVSSCISFYFPC 308
            .:..:|.::|.|||:||.:...|.:     .|..::.   |.|...:| ..||:.||.:|||.|.
Mouse   178 LVCTVWAISALVSFLPILMHWWRAE-----SDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPL 237

  Fly   309 VVMIGIYCRLYCYAQKHVKSIKAVTR-----------------PGEVAEKQRYKSIRRPKNQPKK 356
            .:|..:|.|::..|||.||.|.:..|                 ||.........:.|..|.:|.:
Mouse   238 CIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSR 302

  Fly   357 FKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGY 421
            ...           :.:.||..|:|:|||||.:||:|||..|:..||.:..:..:.|....||||
Mouse   303 LVA-----------LREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGY 356

  Fly   422 SNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRS 486
            :||||||||| ..:.:||.||:|:|      |||:                            |:
Mouse   357 ANSAFNPIIY-CRSPDFRKAFQRLL------CCAR----------------------------RA 386

  Fly   487 SAELEQVSAIXPKC--CLNLTGGGATWLPCGCGGLRVDDDDDGALTT 531
            :..........|:.  ||...|      |....|...|||||.|.||
Mouse   387 ACRRRAAHGDRPRASGCLARAG------PPPSPGAPSDDDDDDAGTT 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	55/131 (42%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	109/306 (36%)
Adrb1	NP_031445.2	7tmA_Beta1_AR	59..376	CDD:320624	117/333 (35%)
		TM helix 1	60..86	CDD:320624	10/25 (40%)
		TM helix 2	93..120	CDD:320624	12/26 (46%)
		TM helix 3	131..161	CDD:320624	15/29 (52%)
		TM helix 4	175..193	CDD:320624	6/17 (35%)
		TM helix 5	221..253	CDD:320624	12/31 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		5/37 (14%)
		TM helix 6	306..336	CDD:320624	15/29 (52%)
		TM helix 7	345..370	CDD:320624	14/25 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..466		14/36 (39%)
		PDZ-Binding. /evidence=ECO:0000250	463..466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910