Protein Alignment Dop1R1 and Adra2b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_033763.3
• Gene: Adra2b / 11552
• MGIID: 87935
• Length: 448
• Species: Mus musculus
• Alignment Length: 443
• Identity: 132/443 - (29%)
• Similarity: 195/443 - (44%)
• Gaps: 125/443 - (28%)

  Fly   121 EPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFA 185
            ||.|:.:...:...::.||..::.||.||.||:.|.||||...||||.|||.||:.||:|::.|:
Mouse     5 EPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFS 69

  Fly   186 GVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIA 250
            ..|:|||||.|...:|:.::|.||:..|:||::|||||:|||..:...|.|....|.|.....|.
Mouse    70 LANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134

  Fly   251 AIWLLAAFVSFVPISLGIHRPDQ-PLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGI 314
            .:||:||.:|..|:   |::.|| |   |.:|  .|.|.|:....|.:.||..||:.||::||.:
Mouse   135 TVWLIAAVISLPPL---IYKGDQRP---EPHG--LPQCELNQEAWYILASSIGSFFAPCLIMILV 191

  Fly   315 YCRLYCYAQK-HVKSIKAVTRPGE----------------------------VAEKQRYKSIRRP 350
            |.|:|..|:: |.:.:.|....||                            |.|...:....|.
Mouse   192 YLRIYVIAKRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPRE 256

  Fly   351 KNQ---PKKFKVRNLHTHSS--PYHVSDHKAAVT------------------------------- 379
            |.:   |:..:.|.|..:.|  |..|.|.|...:
Mouse   257 KEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVF 321

  Fly   380 -------------------------------------------------VGVIMGVFLICWVPFF 395
                                                             :.|::|||::||.|||
Mouse   322 NPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFF 386

  Fly   396 CVNITAAFC-KTC-IGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRIL 446
            ......|.| :.| :....|:...|:||.||:.||:||:|||::||.||:|||
Mouse   387 FSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRIL 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	124/428 (29%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	15/29 (52%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	12/28 (43%)
		TM helix 6	371..401	CDD:320193	12/109 (11%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
Adra2b	NP_033763.3	TM helix 3	85..115	CDD:320444	15/29 (52%)
		TM helix 4	127..150	CDD:320444	8/25 (32%)
		TM helix 5	169..198	CDD:320444	12/28 (43%)
		TM helix 6	362..392	CDD:320444	9/29 (31%)
		TM helix 7	403..428	CDD:320444	11/24 (46%)
		7tmA_alpha2B_AR	7..435	CDD:320444	125/435 (29%)
		TM helix 1	14..40	CDD:320444	8/25 (32%)
		TM helix 2	47..73	CDD:320444	13/25 (52%)