Protein Alignment Dop1R1 and Adra1b

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_031442.2
• Gene: Adra1b / 11548
• MGIID: 104774
• Length: 515
• Species: Mus musculus
• Alignment Length: 350
• Identity: 126/350 - (36%)
• Similarity: 187/350 - (53%)
• Gaps: 52/350 - (14%)

  Fly   123 LSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGV 187
            |.:...:.||:.|...|..::.|||||.|::...|.||...|.|:.:||||||.::..|:.|:..
Mouse    40 LDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSAT 104

  Fly   188 NDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAI 252
            .::||||:.|..|||.|.|.||:|.|||||:|||||:||||.::..|:|...||||.|::.:.::
Mouse   105 LEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSV 169

  Fly   253 WLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCR 317
            |:|:..:|..|: ||...|      ..|..|  .|.:...|.||:.||..|||.|..|::.:|||
Mouse   170 WVLSTVISIGPL-LGWKEP------APNDDK--ECGVTEEPFYALFSSLGSFYIPLAVILVMYCR 225

  Fly   318 LYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVS---------- 372
            :|..|::..|:::|    |.:.|....|.:             .|..||..:|..
Mouse   226 VYIVAKRTTKNLEA----GVMKEMSNSKEL-------------TLRIHSKNFHEDTLSSTKAKGH 273

  Fly   373 ---------------DHKAAVTVGVIMGVFLICWVPFF-CVNITAAFCKTCIGGQTFKILTWLGY 421
                           :.|||.|:|:::|:|::||:||| .:.:.:.|.........||::.||||
Mouse   274 NPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGY 338

  Fly   422 SNSAFNPIIYSIFNKEFRDAFKRIL 446
            .||..|||||...:|||:.||.|||
Mouse   339 FNSCLNPIIYPCSSKEFKRAFMRIL 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	120/337 (36%)
		TM helix 1	130..156	CDD:320193	10/25 (40%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	21/29 (72%)
		TM helix 4	243..265	CDD:320193	6/21 (29%)
		TM helix 5	292..321	CDD:320193	14/28 (50%)
		TM helix 6	371..401	CDD:320193	12/55 (22%)
		TM helix 7	410..435	CDD:320193	13/24 (54%)
Adra1b	NP_031442.2	7tmA_alpha1B_AR	46..359	CDD:320449	120/338 (36%)
		TM helix 1	47..73	CDD:320449	10/25 (40%)
		TM helix 2	80..106	CDD:320449	10/25 (40%)
		TM helix 3	118..148	CDD:320449	21/29 (72%)
		TM helix 4	160..183	CDD:320449	6/23 (26%)
		TM helix 5	200..229	CDD:320449	14/28 (50%)
		TM helix 6	287..317	CDD:320449	12/29 (41%)
		TM helix 7	327..352	CDD:320449	13/24 (54%)
		Nuclear localization signal. /evidence=ECO:0000250	368..378
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..430
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	474..515