Protein Alignment Dop1R1 and Taar1

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_444435.1
• Gene: Taar1 / 111174
• MGIID: 2148258
• Length: 332
• Species: Mus musculus
• Alignment Length: 362
• Identity: 106/362 - (29%)
• Similarity: 162/362 - (44%)
• Gaps: 42/362 - (11%)

  Fly   107 TNASEMDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLA 171
            ||.|..::....|.: .||.|:      :|::|..::.||::|.::|...:.|....|..|.|:|
Mouse     8 TNISHRNSDWSREVQ-ASLYSL------MSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMA 65

  Fly   172 IADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRY 236
            |.|..:..|:|..:.|..:...|.||...|....:.|:|.|:|||.:|..||:|||..:.|||||
Mouse    66 IVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRY 130

  Fly   237 GRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSC 301
            ...:.....::.|...|.|.|..:|..|.|.::......::.........|:...:....|::..
Mouse   131 KAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFM 195

  Fly   302 ISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHS 366
            .|||.|..||:.:|.|:|..|                  |.:.:||.|...|.      .|...|
Mouse   196 TSFYIPGSVMLFVYYRIYFIA------------------KGQARSINRTNVQV------GLEGKS 236

  Fly   367 SPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGGQTFKILTWLGYSNSAFNPIIY 431
            ......:.|||.|:|:::||||:||.|||...:...|....|.......|.|.||.|||.||::|
Mouse   237 QAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVY 301

  Fly   432 SIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRNSDR 468
            :.|...||.|.|.:|           :|.|..::|.|
Mouse   302 AFFYPWFRRALKMVL-----------LGKIFQKDSSR 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	92/311 (30%)
		TM helix 1	130..156	CDD:320193	6/25 (24%)
		TM helix 2	163..189	CDD:320193	9/25 (36%)
		TM helix 3	201..231	CDD:320193	13/29 (45%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	10/28 (36%)
		TM helix 6	371..401	CDD:320193	14/29 (48%)
		TM helix 7	410..435	CDD:320193	10/24 (42%)
Taar1	NP_444435.1	7tmA_TAAR1	25..312	CDD:320438	94/316 (30%)
		TM helix 1	25..50	CDD:320438	8/30 (27%)
		TM helix 2	57..83	CDD:320438	9/25 (36%)
		TM helix 3	95..125	CDD:320438	13/29 (45%)
		TM helix 4	137..160	CDD:320438	6/22 (27%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37963465	174..185		1/10 (10%)
		TM helix 5	186..215	CDD:320438	10/28 (36%)
		TM helix 6	241..271	CDD:320438	14/29 (48%)
		TM helix 7	280..305	CDD:320438	10/24 (42%)