Protein Alignment Dop1R1 and htr2c

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_017951833.1
• Gene: htr2c / 100496012
• XenbaseID: XB-GENE-967634
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 468
• Identity: 128/468 - (27%)
• Similarity: 216/468 - (46%)
• Gaps: 80/468 - (17%)

  Fly    70 LQLTTAKVDLDIEIDIQLLTNGY------DGTTLTSFYNESSWTNASEMDTIVGEEPEPLSLVSI 128
            :.|||..:...::|...   ||.      :..||......|:..||||.:.:..|     ||...
 Frog    11 VSLTTVSITRSVDISFH---NGLMAWHVNNNVTLNQSMPTSAPANASEEEKLSHE-----SLADK 67

  Fly   129 VVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            ....:...::|.|::.|||||.:|:..|:.|:...|.||.|||:||:.|..|||..:.|..|..|
 Frog    68 NWSALLTLIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLVTILYDY 132

  Fly   194 -WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAA 257
             |....:.|..|::.||:.|||||::|||||:|||:.|::|:.:.|:.:|..|::.|||:|
 Frog   133 AWPLPRKLCPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW---- 193

  Fly   258 FVSFVPISLGIHRPDQPLIFEDNGKKY--PTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYC 320
                 .||:||..|...:..:|:.:.:  .:|.|: ...:.::.|.::|:.|.::|:..||....
 Frog   194 -----TISIGISMPVPVIGLQDDSRVFVNSSCVLN-DENFVLLGSFVAFFIPLIIMVFTYCLTIQ 252

  Fly   321 YAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHV-------------- 371
            ..||     :|.....|...|||..|:...|.:.....:..:..|.:..|:
 Frog   253 VLQK-----QATVFMYEEVPKQRRSSVNCLKKENNTENISMIQNHEAASHLNSPINKEGALFRKG 312

  Fly   372 ------SDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTCIGG----QTFKILTWLGYSNSAF 426
                  ::.:|:..:|::..:|||.|.|||..||.:..||.....    :...:..|:||.:|..
 Frog   313 TMQSINNERRASKVLGIVFFLFLIMWCPFFITNIMSVLCKEACDNELMVELLNVFVWVGYVSSGI 377

  Fly   427 NPIIYSIFNKEFRDAF-----------KRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVV 480
            ||::|::||:.:|.||           |:.:..:|.  |..:..:......|           :.
 Frog   378 NPLVYTLFNRTYRRAFASYIRCQYYNSKKTMLQQNQ--CQHNATSTAMYGKD-----------LN 429

  Fly   481 MNSGRSSAELEQV 493
            :||.|:..||..|
 Frog   430 LNSYRNGNELTSV 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	100/338 (30%)
		TM helix 1	130..156	CDD:320193	8/25 (32%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	17/29 (59%)
		TM helix 4	243..265	CDD:320193	5/21 (24%)
		TM helix 5	292..321	CDD:320193	6/28 (21%)
		TM helix 6	371..401	CDD:320193	11/49 (22%)
		TM helix 7	410..435	CDD:320193	7/28 (25%)
htr2c	XP_017951833.1	7tmA_5-HT2C	68..399	CDD:341346	102/345 (30%)
		TM helix 1	69..95	CDD:341346	8/25 (32%)
		TM helix 2	102..128	CDD:341346	13/25 (52%)
		TM helix 3	141..171	CDD:341346	17/29 (59%)
		TM helix 4	183..206	CDD:341346	10/31 (32%)
		TM helix 5	224..253	CDD:341346	6/28 (21%)
		TM helix 6	318..348	CDD:341346	11/29 (38%)
		TM helix 7	361..386	CDD:341346	7/24 (29%)