Protein Alignment Dop1R1 and drd5

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_004911296.1
• Gene: drd5 / 100495174
• XenbaseID: XB-GENE-992519
• Length: 455
• Species: Xenopus tropicalis
• Alignment Length: 370
• Identity: 149/370 - (40%)
• Similarity: 204/370 - (55%)
• Gaps: 38/370 - (10%)

  Fly   114 TIVGEEPEPLSLVS-IVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLF 176
            |:..|..:...||: .:|.|..|.:|||.::.||||||.|:...|.|| |:.|:|:.|||::||.
 Frog    26 TVSHESQQRKELVAGQIVTGSLLLLLIFWTLFGNILVCTAVMRFRHLRNRVTNIFIVSLAVSDLL 90

  Fly   177 VASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVT 241
            ||.|||.:..|.::.|:|.||| |||.|||||:|||||||||||.||:|||..|..|.||.|.:|
 Frog    91 VALLVMPWKAVAEVAGHWPFGA-FCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMT 154

  Fly   242 RRVAVITIAAIWLLAAFVSFVPISLGIHR---PDQPLIFEDNGKKYPTCALDLTPTYAVVSSCIS 303
            :|||::.|:|.|.|:..:||:|:.|..|:   .|..|..:..|    .|...|..|||:.||.||
 Frog   155 QRVALLMISAAWALSVLISFIPVQLSWHKSETDDHLLSNQSTG----NCDSSLNRTYAISSSLIS 215

  Fly   304 FYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSP 368
            ||.|..:||..|.|:|..||..::.|..:.|..|.|:..|...:             :...|.|.
 Frog   216 FYIPVAIMIVTYTRIYRIAQIQIRRISTLERAAEHAQSCRSNRV-------------DCRHHQSS 267

  Fly   369 YHVS---DHKAAVTVGVIMGVFLICWVPFFCVNITAAFCK----------TCIGGQTFKILTWLG 420
            ...|   :.|...|:.:|||||:.||:|||.:|....||.          .|:...||.|..|.|
 Frog   268 LKTSIKKETKVLKTLSIIMGVFVCCWLPFFILNCMVPFCDRSSGHPQAGLPCVSETTFDIFVWFG 332

  Fly   421 YSNSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQDVGNIHPRN 465
            ::||:.|||||: ||.:||..|..:|...: ||....|..::..|
 Frog   333 WANSSLNPIIYA-FNADFRKVFSSLLGCGH-WCSTTPVETVNISN 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	139/328 (42%)
		TM helix 1	130..156	CDD:320193	13/25 (52%)
		TM helix 2	163..189	CDD:320193	13/25 (52%)
		TM helix 3	201..231	CDD:320193	23/29 (79%)
		TM helix 4	243..265	CDD:320193	10/21 (48%)
		TM helix 5	292..321	CDD:320193	15/28 (54%)
		TM helix 6	371..401	CDD:320193	14/32 (44%)
		TM helix 7	410..435	CDD:320193	12/24 (50%)
drd5	XP_004911296.1	TM helix 6	279..301	CDD:410628	11/21 (52%)
		TM helix 7	322..347	CDD:410628	13/25 (52%)
		7tm_GPCRs	42..353	CDD:475119	139/329 (42%)
		TM helix 1	44..68	CDD:410628	12/23 (52%)
		TM helix 2	78..100	CDD:410628	12/21 (57%)
		TM helix 3	115..137	CDD:410628	18/21 (86%)
		TM helix 4	160..176	CDD:410628	6/15 (40%)
		TM helix 5	205..228	CDD:410628	12/22 (55%)