Protein Alignment Dop1R1 and adra2c

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001120375.1
• Gene: adra2c / 100145449
• XenbaseID: XB-GENE-5773399
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 409
• Identity: 128/409 - (31%)
• Similarity: 202/409 - (49%)
• Gaps: 94/409 - (22%)

  Fly   122 PLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRRIGNLFLASLAIADLFVASLVMTFAG 186
            |.|:.|:..:...:..||..::.||:.|.:|:.|.|:|:...||||.|||.||:.||:|||.|:.
 Frog    25 PYSMTSVWCLAAIVGFLIIFTIVGNVFVVIAVLTSRALKAPQNLFLVSLASADILVAALVMPFSL 89

  Fly   187 VNDLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYG-RWVTRRVAVITIA 250
            .|:|:|||.||..:||.::|.||:..|:||::|||||:|||..:...:.|. :...||:..| |.
 Frog    90 ANELMGYWYFGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGI-IV 153

  Fly   251 AIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCI-SFYFPCVVMIGI 314
            .:||::|.:||.|: :.:.|..     ||:  .||.|.|: ..|:.::|||| ||:.||::||.:
 Frog   154 TVWLISAVISFPPL-ISMDRDT-----EDD--VYPQCKLN-DDTWYILSSCIGSFFAPCIIMILV 209

  Fly   315 YCRLYCYAQKHVKSI--KAVTR------------------PGE---------------------- 337
            |.|:|..|:...:::  |..||                  ||:
 Frog   210 YIRIYQVAKLRTRTLSEKKPTRDGSSHTENGFSKGTTVKMPGDKENGHCPPRPSPPKATDVEDLE 274

  Fly   338 -----VAEKQRYKSIRRPKN---------------------------------QPKKFKVRNLHT 364
                 ::|.:|.||..:..|                                 ..:|.|.|:..:
 Frog   275 LEESSMSESKRRKSSSKEDNTDSSKERKCSKGNSFSKQSSRLSRTSNKSMELFSSRKKKKRSSVS 339

  Fly   365 HSSPYHVSDHKAAVTVGVIMGVFLICWVPFFCVNITAAFCK-TCIGGQT-FKILTWLGYSNSAFN 427
            ........:.:....:.|:||||::||.|||........|: .|...:| ||...|:||.||:.|
 Frog   340 RRKLSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPETLFKFFFWIGYCNSSLN 404

  Fly   428 PIIYSIFNKEFRDAFKRIL 446
            |:||:|||::||.:||:|:
 Frog   405 PVIYTIFNQDFRRSFKKII 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	122/395 (31%)
		TM helix 1	130..156	CDD:320193	6/25 (24%)
		TM helix 2	163..189	CDD:320193	15/25 (60%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	9/21 (43%)
		TM helix 5	292..321	CDD:320193	14/29 (48%)
		TM helix 6	371..401	CDD:320193	10/29 (34%)
		TM helix 7	410..435	CDD:320193	13/25 (52%)
adra2c	NP_001120375.1	7tmA_alpha2C_AR	32..419	CDD:320446	122/396 (31%)
		TM helix 1	33..59	CDD:320446	6/25 (24%)
		TM helix 2	66..92	CDD:320446	15/25 (60%)
		TM helix 3	104..134	CDD:320446	16/29 (55%)
		TM helix 4	146..169	CDD:320446	10/24 (42%)
		TM helix 5	187..216	CDD:320446	14/28 (50%)
		TM helix 6	346..376	CDD:320446	10/29 (34%)
		TM helix 7	387..412	CDD:320446	13/24 (54%)