DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and drd7

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001107115.1	Gene:	drd7 / 100002285	ZFINID:	ZDB-GENE-060526-372	Length:	443	Species:	Danio rerio

Alignment Length:	386	Identity:	135/386 - (34%)
Similarity:	198/386 - (51%)	Gaps:	44/386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 LVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVN 188
            |::.......|.:.:..:..||.|||.|:...|.|| ::..:|:.|||::||.||:|||.:....
Zfish    12 LITRSTTACLLFIFVLSTFLGNALVCTAVVRFRHLRSKVAYVFVVSLAVSDLLVATLVMPWKAAA 76

  Fly   189 DLLGYWIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIW 253
            :::|:|.||: ||:.|:|||:|||||||||||.||:|||..|..||.|.:.:|||||.:.|...|
Zfish    77 EIVGFWPFGS-FCEVWIAFDIMCSTASILNLCIISVDRYWAIAIPLSYEQKMTRRVAFVMIGVAW 140

  Fly   254 LLAAFVSFVPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRL 318
            .|:..:||:|:.|..|:...|:  ||..:|   |...|..|||:.||.||||.|..:||..|.|:
Zfish   141 TLSVLISFIPVQLSWHKSIDPI--EDLAEK---CDASLNRTYAITSSLISFYIPVSIMIVTYSRI 200

  Fly   319 YCYAQKHVKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVI 383
            :..||:.::.|.  .:...:...|..:|..:...:..|...|.           :.|...|:.:|
Zfish   201 FLIAQRQIRRIS--MQECSIKHVQSCQSCNKAPEEKLKSSFRR-----------ETKVLKTLSMI 252

  Fly   384 MGVFLICWVPFFCVNITAAFCK---------TCIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFR 439
            ||||:.||:|||.:|....||.         .|:...||.:..|.|::||..||::|: ||.|||
Zfish   253 MGVFVCCWLPFFILNCMVPFCDPGLHNAGQIPCVNKTTFDVFVWCGWANSTLNPVVYA-FNAEFR 316

  Fly   440 DAFKRILTMRNPWCCAQDVGNIHPRNSDRFITDYAAKNVVVMNSGRSSAELEQVSAIXPKC 500
            .||..||.. ...||..:|..:...|.             :::..|.|..|..|... ..|
Zfish   317 KAFSSILGC-GKLCCQNNVQTVDFSNE-------------LVSYHRDSTNLRDVHLFGHPC 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	62/132 (47%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	114/295 (39%)
drd7	NP_001107115.1	7tm_4	25..>150	CDD:304433	60/125 (48%)
drd7	NP_001107115.1	7tm_1	32..309	CDD:278431	114/295 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2313
eggNOG	1	0.900	-	-		E33208_3B9BF
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm24276
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830