Protein Alignment Dop1R1 and htr1aa

DIOPT Version :10

• Sequence 1: NP_001262563.1
• Gene: Dop1R1 / 41726
• FlyBaseID: FBgn0011582
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_001116793.1
• Gene: htr1aa / 100001828
• ZFINID: ZDB-GENE-071203-1
• Length: 398
• Species: Danio rerio
• Alignment Length: 424
• Identity: 129/424 - (30%)
• Similarity: 202/424 - (47%)
• Gaps: 88/424 - (20%)

  Fly    92 YDGTTLTSFYNESSWT-NASEMDTIVGEEPEPLSLVSIVVVG-IFLSVLIFLSVAGNILVCLAIY 154
            |:.||     ....|: ||:.:..:.         :|..::| :||:.||..::.||..|..||.
Zfish     4 YNNTT-----ESQDWSGNATSVSEVA---------LSYQIIGSLFLAALILFAILGNACVIAAIA 54

  Fly   155 TERSLRRIGNLFLASLAIADLFVASLVMTFAGVNDLLGYWIFGAQFCDTWVAFDVMCSTASILNL 219
            .||||:.:.|..:.|||:.||.|:.||:..|.:..:|..|..|.:.||.:::.||:|.|:|||:|
Zfish    55 LERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQEMCDIFISLDVLCCTSSILHL 119

  Fly   220 CAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLGIHRPDQPLIFEDNGKKY 284
            |||::|||..|.||:.|....|.|.|.|.|:..||:...:| :|..||..:|      ||....
Zfish   120 CAIALDRYWAITDPIDYVNKRTPRRAAILISLTWLIGFSIS-IPPMLGWRKP------EDRADP- 176

  Fly   285 PTCALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEK-------- 341
            ..|.:.....|.:.|:..:||.|.::|:.:|.|::..|:..::.....|...::|:|
Zfish   177 DACTISQDHGYTIYSTFGAFYIPLILMLVLYGRIFRAARFRIRKTVKKTEKAKIADKCLAVSPAL 241

  Fly   342 -------QRYKSIRR----------------------------------PKNQPKKFKVRNLHTH 365
                   :..|:.||                                  |.|....|:.||....
Zfish   242 FPRKANGEVGKTWRRSVEPCANGALKNSDDGESFEITEVQSISKNHLSLPNNPQPCFENRNEKNT 306

  Fly   366 SSPYHVS---DHKAAVTVGVIMGVFLICWVPFFCVNITAAFCKTC-----IGGQTFKILTWLGYS 422
            .:...|:   :.|...|:|:|||.|:.||:|||.|.:...||:.|     :|.    ::.|||||
Zfish   307 EAKRKVALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCQDCFMPEWLGA----VINWLGYS 367

  Fly   423 NSAFNPIIYSIFNKEFRDAFKRILTMRNPWCCAQ 456
            ||..||:||:.|||:|::|||:||..:   |..|
Zfish   368 NSLLNPVIYAYFNKDFQNAFKKILKCK---CIRQ 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tmA_Ap5-HTB1-like	130..442	CDD:320193	115/369 (31%)
		TM helix 1	130..156	CDD:320193	10/26 (38%)
		TM helix 2	163..189	CDD:320193	10/25 (40%)
		TM helix 3	201..231	CDD:320193	16/29 (55%)
		TM helix 4	243..265	CDD:320193	8/21 (38%)
		TM helix 5	292..321	CDD:320193	8/28 (29%)
		TM helix 6	371..401	CDD:320193	14/32 (44%)
		TM helix 7	410..435	CDD:320193	11/24 (46%)
htr1aa	NP_001116793.1	7tm_GPCRs	29..387	CDD:475119	115/369 (31%)
		TM helix 1	31..55	CDD:410628	10/23 (43%)
		TM helix 2	64..86	CDD:410628	9/21 (43%)
		TM helix 3	102..124	CDD:410628	12/21 (57%)
		TM helix 4	147..163	CDD:410628	5/16 (31%)
		TM helix 5	185..208	CDD:410628	6/22 (27%)
		TM helix 6	321..343	CDD:410628	12/21 (57%)
		TM helix 7	355..380	CDD:410628	12/28 (43%)