DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dop1R1 and drd6b

DIOPT Version :9

Sequence 1:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_001341592.2	Gene:	drd6b / 100001636	ZFINID:	ZDB-GENE-121214-145	Length:	426	Species:	Danio rerio

Alignment Length:	435	Identity:	161/435 - (37%)
Similarity:	220/435 - (50%)	Gaps:	84/435 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 VVGIFLSVLIFLSVAGNILVCLAIYTERSLR-RIGNLFLASLAIADLFVASLVMTFAGVNDLLGY 193
            :.|..|..||..::.||.|||.|:...|.|| ::.|.|:.|||::|||||.|||.:..|:::.|.
Zfish    18 LTGCALCALILSTLLGNTLVCAAVIKFRHLRSKVTNFFVISLAVSDLFVAVLVMPWKAVSEVAGC 82

  Fly   194 WIFGAQFCDTWVAFDVMCSTASILNLCAISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAF 258
            |:||. |||||:|||:|||||||||||.||:|||..|..|.||.|.:|:|:|.|.|...|.|:..
Zfish    83 WLFGG-FCDTWIAFDIMCSTASILNLCIISLDRYWAISSPFRYERKMTQRMAFIMIGMAWTLSVL 146

  Fly   259 VSFVPISLGIHRPDQPLIFEDNGKKYPT--CALDLTPTYAVVSSCISFYFPCVVMIGIYCRLYCY 321
            :||:|:.|..||.      .|:....|:  |...|..|||:.||.||||.|.::|||.|.|:|..
Zfish   147 ISFIPVKLNWHRA------VDHNLTVPSEDCTASLNRTYAIASSLISFYIPVIIMIGTYTRIYRI 205

  Fly   322 AQKHVKSIKAVTR-PGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMG 385
            ||..::.|..:.| .|....:|...|.:..|:..||                :.|...|:.:|||
Zfish   206 AQTQIRRISILERAAGHAQSQQDCASEQSLKSTFKK----------------ETKVLKTLSIIMG 254

  Fly   386 VFLICWVPFFCVNITAAFCKT-----CIGGQTFKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRI 445
            ||:.||:|||.:|....||.|     |:...||.|..|.|::||:.||:||: ||.:||.||..|
Zfish   255 VFVFCWLPFFVLNCIVPFCDTLGDSPCVSSTTFNIFVWFGWANSSLNPVIYA-FNADFRKAFSTI 318

  Fly   446 LTMRNPWCCAQDVGNIH------------------------------PRNSDRFITDYAAKNV-V 479
            |.. |..|.:..|..::                              |.:.|:  ||.....| |
Zfish   319 LGC-NRLCASSTVETVNFTNELVSYHHDTTLMHKDAQGVSSPRLDLVPGHCDQ--TDVPFDKVSV 380

  Fly   480 VMNSGRSSAELEQVSAIXP-----KCCLNLTGGGATWLPCGCGGL 519
            |.||.|     .|.||: |     :.||::       :|....||
Zfish   381 VSNSSR-----VQRSALLPQDAEMEICLDM-------MPFTSAGL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	69/132 (52%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	125/294 (43%)
drd6b	XP_001341592.2	7tm_4	27..>151	CDD:304433	66/124 (53%)
drd6b	XP_001341592.2	7tm_1	33..305	CDD:278431	125/294 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2313
eggNOG	1	0.900	-	-		E33208_3B9BF
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136216
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3173
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1045889at2759
OrthoFinder	1	1.000	-	-		FOG0001416
OrthoInspector	1	1.000	-	-		otm24276
orthoMCL	1	0.900	-	-		OOG6_107579
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4063
SonicParanoid	1	1.000	-	-		X883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760