DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3199 and KRT20

DIOPT Version :9

Sequence 1:	NP_650342.2	Gene:	CG3199 / 41725	FlyBaseID:	FBgn0038210	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_061883.1	Gene:	KRT20 / 54474	HGNCID:	20412	Length:	424	Species:	Homo sapiens

Alignment Length:	181	Identity:	43/181 - (23%)
Similarity:	56/181 - (30%)	Gaps:	68/181 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FDRNLPVFSFDLVITRLEVKG--VVLADARKLLVKVKFGGNNLSLTASRTNVSEFKPNASHTFQA 95
            |:|...|....:.:...|:||  |.|.:.|                  ||:.|......||....
Human   261 FERQTAVLQQQVTVNTEELKGTEVQLTELR------------------RTSQSLEIELQSHLSMK 307

  Fly    96 EPPNLAQTVEENGIDFEVVYDEQVVGLGKL--SLPKRL------------STRIKLDMKAFSYTS 146
            |  :|..|:||.    :..|..|:..|..|  ||..:|            ...|.||:|.
Human   308 E--SLEHTLEET----KARYSSQLANLQSLLSSLEAQLMQIRSNMERQNNEYHILLDIKT----- 361

  Fly   147 TCPLEMEGKPVGALEFLCKLFIKCGDYAR--EGETCPNLDRNLS---PRDI 192
              .||.|                ...|.|  |||.....:..||   .|||
Human   362 --RLEQE----------------IATYRRLLEGEDVKTTEYQLSTLEERDI 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3199	NP_650342.2	DUF4788	45..>216	CDD:292651	40/169 (24%)
KRT20	NP_061883.1	Head	1..69
		Filament	69..380	CDD:306535	38/165 (23%)
		Coil 1A	70..105
		Linker 1	106..123
		Coil 1B	124..215
		Linker 12	216..238
		Coil 2	239..377		36/162 (22%)
		Tail	378..424		5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900