Protein Alignment RpII140 and POLR1B

DIOPT Version :9

• Sequence 1: NP_001287323.1
• Gene: RpII140 / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: NP_001358898.1
• Gene: POLR1B / 84172
• HGNCID: 20454
• Length: 1181
• Species: Homo sapiens
• Alignment Length: 1291
• Identity: 367/1291 - (28%)
• Similarity: 551/1291 - (42%)
• Gaps: 303/1291 - (23%)

  Fly    40 LVRQQLDSFD----EFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPP-RFSLKFEQI------- 92
            |.|..::||:    |.:.::||.|                      || .|:.|.|:|
Human    38 LTRAHVESFNYAVHEGLGLAVQAI----------------------PPFEFAFKDERISFTILDA 80

  Fly    93 YLSKPTHWEKDGS---PSPMMPNEARLRNLTYSAPLYVDITKTKN--VEGLDPVETQHQKTFIGK 152
            .:|.||  ...|:   .:.:.|.|.|.|..||...|..||....|  .:|:       .|.|:|.
Human    81 VISPPT--VPKGTICKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGI-------IKQFLGY 136

  Fly   153 IPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVL-------------IAQEKMATN 204
            :|||::|..|.|..|..:.|.|.:|...:.||||||||.|||:             :.:.|..|.
Human   137 VPIMVKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTR 201

  Fly   205 ----TVYVFSMKDGKYAFKTEIRSCL--EHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPY 263
                |.|..||            .|:  |||:       |||.....:|      |..::..: |
Human   202 GPGYTQYGVSM------------HCVREEHSA-------VNMNLHYLEN------GTVMLNFI-Y 240

  Fly   264 IKQ--EIPIMIVFRALGFVADRDILEHIIYDFDDPEMM-----EMVKPSLDEAFVVQEQNVALNF 321
            .|:  .:|:....:||...:|..|.:.:|...:|...:     :|::..::|....|:|  .||:
Human   241 RKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQ--VLNY 303

  Fly   322 IGARGARPGVTKDKRIKYAKEILQKEMLPHVGVSDF------C-----ETKKAYFLGYMVHRLLL 375
            :|         :..|:|    :...:..|:...::|      |     .|:|.|.|..|..:|..
Human   304 LG---------ECFRVK----LNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLFA 355

  Fly   376 ASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGLFKNLMKEVRMYTQKFIDRGKDFNLELAIKTN- 439
            .:.|....|:.|...|:.:...|.|.....:...:..:..:::...|     |.....:::.|:
Human   356 LAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDK-----KAQKTSVSMNTDN 415

  Fly   440 ---IITDGL------RYSLATGNWGDQKKAHQAR-AGVSQVLNRLTFASTLSHLRRVNSPIGRDG 494
               |.|.|:      .|..||||...:......: :|:..|.::|.|...|||.|.|:    |..
Human   416 LMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVH----RGA 476

  Fly   495 KLAK-----PRQLHNTLWGMLCPAETPEGAAVGLVKNLALMA-----YISVGSQPSPILEFLEEW 549
            ..||     .|:|....||.|||..||:|...||:.:|..:.     ::...|.|:    .|...
Human   477 DFAKMRTTTVRRLLPESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPA----LLCNL 537

  Fly   550 SMENLEEIAPSAIADATKIFVNGCWVG-IHRDPEQLMA-TLRKL-------RRQMDIIV------ 599
            .:..::.....:.::...:.::|..|| :.:|....:| :||..       |.|...::
Human   538 GVTPIDGAPHRSYSECYPVLLDGVMVGWVDKDLAPGIADSLRHFKSLALSPRLQCSGVILAHCSL 602

  Fly   600 ---------SEVSMIRDIRD--------REIRI-----------------------YTDAGRICR 624
                     :.||.:..|..        ||.||                       :|...|:.|
Human   603 RLPCSSNSPASVSQVAGITGAHHHAWVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVR 667

  Fly   625 PLLIVENGSLLLKKTHVEMLKERDYNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLKQDKDY 689
            |   |:|                          :|.|..|.|.|:|:..:.:|     :.:|:.:
Human   668 P---VQN--------------------------LALGKEELIGTMEQIFMNVA-----IFEDEVF 698

  Fly   690 AYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLY 754
            |..|  ||.|:.|..:|.|.|:.|||.||||||||.||..||||.||..:..:..|.|...:.|.
Human   699 AGVT--THQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQDRSDNKLYRLQ 761

  Fly   755 YPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRS-YKD 818
            .|..|||.....:|......|.|.|:|||::.||||:.||::|:|.::.||||.....|:| :.|
Human   762 TPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAHGSVYKSEFID 826

  Fly   819 -SENKRVGDQEENFE-KPHRGTCQGMRNAHYDKLDDDGIIAPGIRVS-GDDVVIGKTITLPENDD 880
             ||..:.||....|. ||  |..:.::     ||||||:...|.::. ||...           .
Human   827 LSEKIKQGDSSLVFGIKP--GDPRVLQ-----KLDDDGLPFIGAKLQYGDPYY-----------S 873

  Fly   881 ELDSNTKRFSKRDASTFL---RNSETGIVDQVMLTLNSEG---YKFCKIRVRSVRIPQIGDKFAS 939
            .|:.||       ..:|:   ::.|..:||.:.:..|..|   :|...|.:|..|.|.|||||||
Human   874 YLNLNT-------GESFVMYYKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFAS 931

  Fly   940 RHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPF 1004
            ||||||.....:..|||.||..|:.|||:.|||..|||||||.|||.:.||..:..|...|||||
Human   932 RHGQKGILSRLWPAEDMPFTESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPF 996

  Fly  1005 -----NDAVNVQKISTFLQEYGYHLRGNEVMYNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSR 1064
                 |.|  ::.....|:..||:..|.|.:|:|.:|.::.|.:|:|..|||||:|||.||...|
Human   997 IFSEENSA--LEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRHMVSDKFQVR 1059

  Fly  1065 ARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYRVHICNFCGLI-- 1127
            ..|....:..||:.||...||:||||||||..::||.:..|.:|||..||....|:|..||.:
Human  1060 TTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRLFNCSDRSVAHVCVKCGSLLS 1124

  Fly  1128 --------AIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQELMSMNIAPRLMV 1175
                    :.:.:||..:.|..|.....|..|.:||..:....||.:|||..:|.|
Human  1125 PLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFVAELAAMNIKVKLDV 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	367/1291 (28%)
POLR1B	NP_001358898.1	RNA_pol_B_RPB2	38..1179	CDD:238353	365/1288 (28%)
		RNA_pol_Rpb2_2	186..375	CDD:367992	46/229 (20%)
		RNA_pol_Rpa2_4	563..662	CDD:369122	16/98 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820