Protein Alignment Polr2B and NRPA2

DIOPT Version :10

• Sequence 1: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: NP_564341.2
• Gene: NRPA2 / 839872
• AraportID: AT1G29940
• Length: 1178
• Species: Arabidopsis thaliana
• Alignment Length: 1274
• Identity: 345/1274 - (27%)
• Similarity: 560/1274 - (43%)
• Gaps: 229/1274 - (17%)

  Fly    29 IVINA----------YFDEKGLVRQQLDSFD----EFIQMSVQRIVEDSPAIELQAEAQHTSGE- 78
            :|:||          :.:...||...::|||    :.:.:...||   .|   :.....:|..|
plant     1 MVVNAKDSTVPTMEDFKELHNLVTHHIESFDYMTLKGLDVMFNRI---KP---VSVYDPNTENEL 59

  Fly    79 ---VETPPRFSLKFEQIYLSKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVDITKTKNVEGLDP 140
               :|.|..|:.:.|.        ::......|::|.|.|...::|:.....|:....|    |.
plant    60 SIWLENPLVFAPQKES--------FKSTSRKEPLLPFECRQAKISYTGTFMADVCFKYN----DG 112

  Fly   141 VETQHQKTFIGKIPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKV---LIAQEKMA 202
            |..:.:..| |:.||||.|..|.|.....|.|.:..|...:.|||||:||.|:|   :||.::..
plant   113 VVVRDKFDF-GQFPIMLMSKLCSLKGADCRKLLKCKESTSEMGGYFILNGIERVFRCVIAPKRNH 176

  Fly   203 TNTVYVFSMKDGK--YAFKTEIRSCLEHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPYIK 265
            ..::...|.:|.|  |:.|..:..|: ...:.:.|:.:..:..||..:....:|:..:
plant   177 PTSMIRNSFRDRKEGYSSKAVVTRCV-RDDQSSVTVKLYYLRNGSARVGFWIVGREYL------- 233

  Fly   266 QEIPIMIVFRALGFVADRDILEHIIYDFDD-----------PEMMEMVKPSLDE----AFVVQEQ 315
              :|:.:|.:||....|.:|.|.:...:.:           ..:.|..|..|||    ....:||
plant   234 --LPVGLVLKALTNSCDEEIYESLNCCYSEHYGRGDGAIGTQLVRERAKIILDEVRDLGLFTREQ 296

  Fly   316 ---NVALNFIGARGARPGVTKDKRIKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAS 377
               ::..:|   :....||.|:.....|:.:|:..:..|:.    .:..|...|.:::.: |.:.
plant   297 CRKHLGQHF---QPVLDGVKKESLSIVAEAVLRDYLFVHLD----NDHDKFNLLIFIIQK-LYSL 353

  Fly   378 LGRREL-DDRDHYGNKRLDLAGPLLAFLFRGLF-------KNLMKEVRMYT------------QK 422
            :.:..| |:.|...|:.:.:.|.::....:...       |:|:|:....|            :|
plant   354 VDQTSLPDNPDSLQNQEILVPGHVITIYLKEKLEEWLRKCKSLLKDELDNTNSKFSFESLADVKK 418

  Fly   423 FIDRGKDFNLELAIKTNIITDGLRYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRVN 487
            .|::....::..:|:|.:.|..|:    |.:..|.    |.|||.:....||.|...||..|.|:
plant   419 LINKNPPRSIGTSIETLLKTGALK----TQSGLDL----QQRAGYTVQAERLNFLRFLSFFRAVH 475

  Fly   488 SPIGRDG-KLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYI-SVGSQPSPILEFLE--- 547
            ......| :....|:|....||.|||..||:|...||:.::...:.| |.......|.:||:
plant   476 RGASFAGLRTTTVRKLLPESWGFLCPVHTPDGTPCGLLNHMTRTSRITSQFDSKGNIRDFLKIRK 540

  Fly   548 --------EWSMENLEEIAPSAIADATKIFVNGCWVGIHRDPEQLMATLRKLRRQMDIIVSEVSM 604
                    ...:.:|.::..:.......:.::|          |::.||     ..:::...||.
plant   541 SVVDVLTGAGMVPSLPKLVRAGPPKVIHVLLDG----------QVVGTL-----SSNLVTKVVSY 590

  Fly   605 IRDIRDREIRIYTDAGRICRPLLIVEN-----------GS---LLLKKTHVEMLKERDYNNYSWQ 655
            ||       |:..:|     |.:|.|:           ||   |.|.......:  |...|.|
plant   591 IR-------RLKVEA-----PSVIPEDLEVGYVPTSMGGSYPGLYLASCPARFI--RPVKNIS-- 639

  Fly   656 VLVASGVVEYIDTLEEETVMIAMSPYD----LKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFP 716
              :.|..:|.|...|:  |.:.:|..|    .:.:...|     ||.||||..::.|.|::.|:.
plant   640 --IPSDNIELIGPFEQ--VFMEISCPDGGNGGRNNSSLA-----THEEIHPTGMISVVANLTPWS 695

  Fly   717 DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSI 781
            ||||||||.||..|.||.|.........|.|...:.|..|..|:|.|::.......|.|.|.|:|
plant   696 DHNQSPRNMYQCQMAKQTMAYSTQALQFRADQKIYHLQTPQSPVVRTKTYTTYSIDENPTGTNAI 760

  Fly   782 VAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEKPHRGTCQGMRNAH 846
            ||:|.:||::.||::|||.|:||||......|:    :||..:.||...|:...:...:....|.
plant   761 VAVLAHTGFDMEDAMILNKSSVERGMCHGQIYQ----TENIDLSDQNSRFDSGSKSFRRSTNKAE 821

  Fly   847 YDKLDDDGIIAPGIRVSGDDVVIGKTITLPENDDELDSNTKRFSKRDASTFLRNSETGIVDQVML 911
            :.::|.||:.:.|.::..|:......       ||:.:.|:...:       :.::..|||.|.:
plant   822 HFRIDADGLPSVGQKLYPDEPYCSIY-------DEVTNKTRHMKR-------KGTDPVIVDFVSV 872

  Fly   912 TLNSEGY-KFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFT-CEGLAPDIIINPHAI 974
            .:.|:.: :...||.|..|.|.|||||:|||||||.|...:...||.|. ..|:.||:||||||.
plant   873 DMKSKKHPQRANIRFRHARNPIIGDKFSSRHGQKGVCSQLWPDIDMPFNGVTGMRPDLIINPHAF 937

  Fly   975 PSRMTIGHLIECLQGKLGSNKGEIGDATPFNDAVN-------------VQKISTFLQEYGYHLRG 1026
            ||||||..|:|.:..|.||..|:..|||||.|||.             |..:.:.|:|.|::..|
plant   938 PSRMTIAMLLESIAAKGGSLHGKFVDATPFRDAVKKTNGEEESKSSLLVDDLGSMLKEKGFNHYG 1002

  Fly  1027 NEVMYNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEM 1091
            .|.:|:|:.|.::..::|:||.|||||:|||.||...|:.|.|..|..||::||.|.||:|||||
plant  1003 TETLYSGYLGVELKCEIFMGPVYYQRLRHMVSDKFQVRSTGQVDQLTHQPIKGRKRGGGIRFGEM 1067

  Fly  1092 ERDCQISHGAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRN-------------------NTF 1137
            |||..::|||:..|.:||...||.:...:|:.||.:..:::.|                   ...
plant  1068 ERDSLLAHGASYLLHDRLHTSSDHHIADVCSLCGSLLTSSVVNVQQKKLIQEIGKLPPGRTPKKV 1132

  Fly  1138 ECKGCKNKTQISQVRLPYAAKLLFQELMSMNIAPRLMVT 1176
            .|..||....:..|.:||..:.|..||.||||...|.::
plant  1133 TCYSCKTSKGMETVAMPYVFRYLAAELASMNIKMTLQLS 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	345/1272 (27%)
NRPA2	NP_564341.2	RNA_pol_B_RPB2	22..1169	CDD:238353	341/1249 (27%)
		RNA_pol_Rpb2_2	193..372	CDD:398318	34/196 (17%)
		RNA_pol_Rpa2_4	576..633	CDD:462028	15/75 (20%)