DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII140 and Polr1b

DIOPT Version :9

Sequence 1:	NP_001287323.1	Gene:	RpII140 / 41721	FlyBaseID:	FBgn0262955	Length:	1176	Species:	Drosophila melanogaster
Sequence 2:	NP_113961.2	Gene:	Polr1b / 83582	RGDID:	620822	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1246	Identity:	361/1246 - (28%)
Similarity:	539/1246 - (43%)	Gaps:	259/1246 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKFEQIYLSKPTHWEKDG 104
            |.|..:|||:..:...:...|:..|..|                 |:.|.|:|.|:     ..|.
  Rat    38 LTRAHVDSFNYAVLEGLSHAVQAIPPFE-----------------FAFKDERISLT-----IVDA 80

  Fly   105 SPSP-------------MMPNEARLRNLTYSAPLYVDITKTKN--VEGLDPVETQHQKTFIGKIP 154
            :.||             :.|.|.|.|..||...|..||:...|  .:|:       .|.|:|.:|
  Rat    81 AISPPAVPKGTICKELNIYPAECRGRRSTYRGKLTADISWAVNGVPKGI-------IKQFLGYVP 138

  Fly   155 IMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVL-------------IAQEKMATNTV 206
            ||::|..|.|..|..:.|.|.:|...:.||||||||.|||:             :.:.|..:..:
  Rat   139 IMVKSKLCNLYNLPPQVLIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKSRGL 203

  Fly   207 YVFSMKDGKYAFKTEIRSCL--EHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPYIKQ--E 267
                   |...|...|. |:  |||:       |||.....:|      |..::..: |.|:  .
  Rat   204 -------GYTQFGVSIH-CVREEHSA-------VNMNLHYVEN------GTVMLNFI-YRKELFF 246

  Fly   268 IPIMIVFRALGFVADRDILEHIIY-----DFDDPEMMEMVKPSLDEAFVVQEQNVALNFIGARGA 327
            :|:....:||...:|..|.:.:|.     .|....:.:|::..::|....|:|  .|:::|.|
  Rat   247 LPLGFALKALVSFSDYQIFQELIKGKEEDSFFKNSVSQMLRIVMEEGCHTQKQ--VLDYLGER-- 307

  Fly   328 RPGVTKDKRIKYAKEILQKEMLPHVGVSDF------C-----ETKKAYFLGYMVHRLLLASLGRR 381
                       :..::...:..|:...::|      |     .|.|.|.|..|..:|...:.|..
  Rat   308 -----------FRVKLSLPDWYPNAEAAEFLFNQCICIHLKSNTDKFYLLCLMTRKLFALARGEC 361

  Fly   382 ELDDRDHYGNKRLDLAGPLLAFLFRGLFKNLMKEVRMYTQKFIDRGKDFNLELAIKTNI------ 440
            ..|:.|...|:.:...|.|.....:...:|.:..:::...|           .|.|||:
  Rat   362 MEDNPDSLVNQEVLTPGQLFLMFLKEKMENWLLSIKIALDK-----------RAQKTNVSINNEN 415

  Fly   441 ----------ITDGLRYSLATGNWGDQK-KAHQARAGVSQVLNRLTFASTLSHLRRVNSPIGRDG 494
                      :|....|.|||||...:. ......:|:..|.::|.|...|||.|.|:    |..
  Rat   416 LMKIFSMGTELTRPFEYLLATGNLRSKTGLGFMQDSGLCVVADKLNFIRYLSHFRCVH----RGA 476

  Fly   495 KLAK-----PRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENL 554
            ..||     .|:|....||.|||..||:||..||:.:|..:..:        :.:|:...|:..|
  Rat   477 DFAKMRTTTVRKLLPESWGFLCPVHTPDGAPCGLLNHLTAVCEV--------VTKFVYTASIPAL 533

  Fly   555 --------EEIAP-SAIADATKIFVNGC---WVGIHRDPEQLMATLRK---LRRQMDIIVSEVSM 604
                    .:.|| ...:|...:.::|.   ||.....|| :..|||:   ||.:......||::
  Rat   534 LCGLGVTPVDAAPCRPYSDCYPVLLDGVMVGWVDKELAPE-VADTLRRFKVLRERRVPPWMEVAL 597

  Fly   605 I----RDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERDYNNYSWQVLVASGVVEY 665
            |    :......:.::|...|:.||   |:|         :|:.||                 |.
  Rat   598 IPMTGKPSLYPGLFLFTTPCRLVRP---VQN---------LELGKE-----------------EL 633

  Fly   666 IDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAM 730
            :.|:|:..:.||:.       :|..:....||.|:.|..:|.|.|:.|||.||||||||.||..|
  Rat   634 VGTMEQLFMNIAIF-------EDEVFGGVSTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQM 691

  Fly   731 GKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDS 795
            |||.||..:..:..|.|...:.|..|..|||.....::......|.|.|:|||::.||||:.||:
  Rat   692 GKQTMGFPLLTYQDRSDNKLYRLQTPQSPLVRPCMYDHYDMDNYPIGTNAIVAVISYTGYDMEDA 756

  Fly   796 VILNASAVERGFFRSVFYRS-YKD-SENKRVGDQEENF-EKPHRGTCQGMRNAHYDKLDDDGIIA 857
            :|:|.::.||||.....|:| :.| ||..:.||....| .||  |..:.|:     |||:||:..
  Rat   757 MIVNKASWERGFAHGSVYKSEFIDLSEKFKQGDDSLVFGVKP--GDPRVMQ-----KLDNDGLPF 814

  Fly   858 PGIRVSGDDVVIGKTITLPENDDELDSNTKRFSKRDASTFLRNSETGIVDQVMLTLNSEG---YK 919
            .|.::...|...|          .|:.||    ......:.::.|..:||.:.:..|..|   :|
  Rat   815 IGAKLEFGDPYYG----------YLNLNT----GEGFVVYYKSKENCVVDNIKVCSNDTGSGKFK 865

  Fly   920 FCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHAIPSRMTIGHLI 984
            ...:.||..|.|.|||||||||||||.....:..|||.||..|:.|||:.|||..|||||||.||
  Rat   866 CVCVTVRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMMPDILFNPHGFPSRMTIGMLI 930

  Fly   985 ECLQGKLGSNKGEIGDATPF-----NDAVNVQKISTFLQEYGYHLRGNEVMYNGHTGRKINAQVF 1044
            |.:.||..:..|...|||||     |.|  ::.....|:..||:..|.|.:|:|.:|.::.|.:|
  Rat   931 ESMAGKSAALHGLCHDATPFIFSEENSA--LEYFGEMLKAAGYNFYGTERLYSGISGMELEADIF 993

  Fly  1045 LGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAAQFLRERL 1109
            :|..|||||:|||.||...|..|....:..||:.||...||:||||||||..::||.:..|.:||
  Rat   994 IGVVYYQRLRHMVSDKFQVRTTGARDKVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLLHDRL 1058

  Fly  1110 FEVSDPYRVHICNFCGLI----------AIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQEL 1164
            |..||....|:|..||.:          :.:.:||..:.|..|.....|..|.:||..:....||
  Rat  1059 FNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTVCGRSDSIDTVSVPYVFRYFVAEL 1123

  Fly  1165 MSMNIAPRLMV 1175
            .:|||..:|.|
  Rat  1124 AAMNIKVKLDV 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	361/1246 (29%)
Polr1b	NP_113961.2	RNA_pol_B_RPB2	38..1133	CDD:238353	359/1243 (29%)
		RNA_pol_Rpb2_2	186..375	CDD:398318	42/225 (19%)
		RNA_pol_Rpa2_4	563..616	CDD:399696	13/53 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820