DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII140 and NRPC2

DIOPT Version :9

Sequence 1:	NP_001287323.1	Gene:	RpII140 / 41721	FlyBaseID:	FBgn0262955	Length:	1176	Species:	Drosophila melanogaster
Sequence 2:	NP_001332060.1	Gene:	NRPC2 / 834550	AraportID:	AT5G45140	Length:	1161	Species:	Arabidopsis thaliana

Alignment Length:	1182	Identity:	423/1182 - (35%)
Similarity:	667/1182 - (56%)	Gaps:	92/1182 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKFEQIYL 94
            ::..:...:|||:|.||||:.||.:.:.:||        :|.::.||   ...|...|:|:::.:
plant    35 LVPEFLKVRGLVKQHLDSFNYFINVGIHKIV--------KANSRITS---TVDPSIYLRFKKVRV 88

  Fly    95 SKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVDITKTKNVEGLDPVETQHQKTFIGKIPIMLRS 159
            .:|:....: :...:.|:..||.::||:||::|:|.......| :..::......||::||||||
plant    89 GEPSIINVN-TVENINPHMCRLADMTYAAPIFVNIEYVHGSHG-NKAKSAKDNVIIGRMPIMLRS 151

  Fly   160 TYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGKYAFKTEIRS 224
            ..|:|....:.:|..|.||||||||||||.|:||||:.||:::.|.:.:.|.|.|      .|.:
plant   152 CRCVLHGKDEEELARLGECPLDPGGYFIIKGTEKVLLIQEQLSKNRIIIDSDKKG------NINA 210

  Fly   225 CLEHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALGFVADRDILEHI 289
            .:..|:..|.:..|..|.:           ::|...|....::|||:||.:|:|..:|::|::.:
plant   211 SVTSSTEMTKSKTVIQMEK-----------EKIYLFLHRFVKKIPIIIVLKAMGMESDQEIVQMV 264

  Fly   290 IYDFDDPEMMEMVKPSLDEAFV--VQEQNVALNFIGARGARPGVTKDKRIKY---------AKEI 343
               ..||.....:.||::|...  |..|..||:::.|        |.|:|.|         |..|
plant   265 ---GRDPRFSASLLPSIEECVSEGVNTQKQALDYLEA--------KVKKISYGTPPEKDGRALSI 318

  Fly   344 LQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGL 408
            |:...|.||.|.|....:|.:::|.|:.|::.|.|.:..:||:|:.|||||:|:|.|::.||..|
plant   319 LRDLFLAHVPVPDNNFRQKCFYVGVMLRRMIEAMLNKDAMDDKDYVGNKRLELSGQLISLLFEDL 383

  Fly   409 FKNLMKEVRMYTQKFID---RGKDFNLELAIKTN---IITDGLRYSLATGNWGDQKKAHQARAGV 467
            ||.::.|........::   |...|:....:..:   .|:.||..:|:|||: |.|:....|.|:
plant   384 FKTMLSEAIKNVDHILNKPIRASRFDFSQCLNKDSRYSISLGLERTLSTGNF-DIKRFRMHRKGM 447

  Fly   468 SQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAY 532
            :|||.||:|..::..:.:::....:..|::.||.|..:.||||||.:||||.:.|||||||||.:
plant   448 TQVLTRLSFIGSMGFITKISPQFEKSRKVSGPRSLQPSQWGMLCPCDTPEGESCGLVKNLALMTH 512

  Fly   533 ISVGSQPSPILEFLEEWSMENLEEIAPSAI--ADATKIFVNGCWVGIHRDPEQLMATLRKLRRQM 595
            ::...:..|::....:..:.:||.::...:  .|:..:.:||..:|.|..|:....:||:|||..
plant   513 VTTDEEEGPLVAMCYKLGVTDLEVLSAEELHTPDSFLVILNGLILGKHSRPQYFANSLRRLRRAG 577

  Fly   596 DIIVSE-VSMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKE--RDYNNYSWQVL 657
            .|  .| ||:..:.:...:.:.:|.||:||||:|.:.|...:|:.|::.|::  |.::::
plant   578 KI--GEFVSVFTNEKQHCVYVASDVGRVCRPLVIADKGISRVKQHHMKELQDGVRTFDDF----- 635

  Fly   658 VASGVVEYIDTLEEETVMIAMSPYD----LKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDH 718
            :..|::||:|..||...:||:...|    |.:..:.|...| ||.||.|..||||.|.:||:|.|
plant   636 IRDGLIEYLDVNEENNALIALYESDGTTELDEGAEAAKADT-THIEIEPFTILGVVAGLIPYPHH 699

  Fly   719 NQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVA 783
            |||||||||.||||||||....|...|||||.::|.||.:||:|||::|.:.:.:|.||.|:.||
plant   700 NQSPRNTYQCAMGKQAMGNIAYNQLNRMDTLLYLLVYPQRPLLTTRTIELVGYDKLGAGQNATVA 764

  Fly   784 ILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEKPHRGTCQGMRNAHYD 848
            ::.::||:.||::::|.|:::|||.|.:..:.......|......:....|.|   .|.......
plant   765 VMSFSGYDIEDAIVMNKSSLDRGFGRCIVMKKIVAMSQKYDNCTADRILIPQR---TGPDAEKMQ 826

  Fly   849 KLDDDGIIAPGIRVSGDDVVIGKTITLPENDDELDSNTKRFSK---RDASTFLR--NSETGIVDQ 908
            .|||||:..||..:..:|:.|.|.:.:    |.:...|...|.   |.|..:.:  ..||.:||:
plant   827 ILDDDGLATPGEIIRPNDIYINKQVPV----DTVTKFTSALSDSQYRPAREYFKGPEGETQVVDR 887

  Fly   909 VMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHA 973
            |.|..:.:|....|..:|..|.|::||||:|||||||.|||..:|||..|:..|:.||:|:|||.
plant   888 VALCSDKKGQLCIKYIIRHTRRPELGDKFSSRHGQKGVCGIIIQQEDFPFSELGICPDLIMNPHG 952

  Fly   974 IPSRMTIGHLIECLQGKLGSNKGEIGDATPFND----AVNVQKISTFLQEYGYHLRGNEVMYNGH 1034
            .|||||:|.:||.|..|.|.:.|.....:.|.:    |..|:.||..|.|.|:...|.:::|:|.
plant   953 FPSRMTVGKMIELLGSKAGVSCGRFHYGSAFGERSGHADKVETISATLVEKGFSYSGKDLLYSGI 1017

  Fly  1035 TGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISH 1099
            :|..:.|.:|:||.|||:|||||.||:|:|..||..::.|||.||::::||||.|||||||.|::
plant  1018 SGEPVEAYIFMGPIYYQKLKHMVLDKMHARGSGPRVMMTRQPTEGKSKNGGLRVGEMERDCLIAY 1082

  Fly  1100 GAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQEL 1164
            ||:..:.|||...|||:.|.:|..|||:...|.:.....|..|||...|:.::||||.|||||||
plant  1083 GASMLIYERLMISSDPFEVQVCRACGLLGYYNYKLKKAVCTTCKNGDNIATMKLPYACKLLFQEL 1147

  Fly  1165 MSMNIAPRLMVT 1176
            .|||:.|||.:|
plant  1148 QSMNVVPRLKLT 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	422/1180 (36%)
NRPC2	NP_001332060.1	RNA_pol_B_RPB2	45..1157	CDD:238353	420/1168 (36%)
		RNA_pol_Rpb2_4	550..611	CDD:398322	22/62 (35%)
		RNA_pol_Rpb2_5	632..683	CDD:398323	16/56 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720