DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII140 and NRPB2

DIOPT Version :9

Sequence 1:	NP_001287323.1	Gene:	RpII140 / 41721	FlyBaseID:	FBgn0262955	Length:	1176	Species:	Drosophila melanogaster
Sequence 2:	NP_193902.1	Gene:	NRPB2 / 828259	AraportID:	AT4G21710	Length:	1188	Species:	Arabidopsis thaliana

Alignment Length:	1185	Identity:	776/1185 - (65%)
Similarity:	933/1185 - (78%)	Gaps:	26/1185 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDNEEELYEEENAEEISHELWQEACWIVINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIE 67
            |:.|.:..|:::.|||:    ||..|.||:|||:|||||||||||||||||.::|.||::|..||
plant     6 YEPEPQYVEDDDDEEIT----QEDAWAVISAYFEEKGLVRQQLDSFDEFIQNTMQEIVDESADIE 66

  Fly    68 LQAEAQHTSGE----VETPPRFSLKFEQIYLSKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVD 128
            ::.|:||..|.    .||  .:.:.|.|||||||...|.||..:.:.|..|||||||||||||||
plant    67 IRPESQHNPGHQSDFAET--IYKISFGQIYLSKPMMTESDGETATLFPKAARLRNLTYSAPLYVD 129

  Fly   129 ITK---TKNVEGLDPVETQ-HQKTFIGKIPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIIN 189
            :||   .|..:|.:..||| ..|.||||:||||||:||.|.|.:::|||||.|||.|.|||||||
plant   130 VTKRVIKKGHDGEEVTETQDFTKVFIGKVPIMLRSSYCTLFQNSEKDLTELGECPYDQGGYFIIN 194

  Fly   190 GSEKVLIAQEKMATNTVYVFSMKD-GKYAFKTEIRSCLEHSSRPTSTLWVNMMARGSQNIKKSAI 253
            ||||||||||||:||.||||..:. .|||:..|:||..|:.:||.||::|.|:||.|  .|..:.
plant   195 GSEKVLIAQEKMSTNHVYVFKKRQPNKYAYVGEVRSMAENQNRPPSTMFVRMLARAS--AKGGSS 257

  Fly   254 GQRIIAILPYIKQEIPIMIVFRALGFVADRDILEHIIYDFDDPEMMEMVKPSLDEAFVVQEQNVA 318
            ||.|...||||:.||||:|||||||||||:||||||.|||.|.:|||:::|||:||||:|.|.||
plant   258 GQYIRCTLPYIRTEIPIIIVFRALGFVADKDILEHICYDFADTQMMELLRPSLEEAFVIQNQLVA 322

  Fly   319 LNFIGARGARPGVTKDKRIKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRREL 383
            |::||.|||..||||:||||||::|||||||||||:.:.|||||||:.||::|||||.:||||..
plant   323 LDYIGKRGATVGVTKEKRIKYARDILQKEMLPHVGIGEHCETKKAYYFGYIIHRLLLCALGRRPE 387

  Fly   384 DDRDHYGNKRLDLAGPLLAFLFRGLFKNLMKEVRMYTQKFIDRGKDFNLELAIKTNIITDGLRYS 448
            ||||||||||||||||||..|||.||:.|.::||.|.||.:|.||:.||:.|||...||.||:||
plant   388 DDRDHYGNKRLDLAGPLLGGLFRMLFRKLTRDVRSYVQKCVDNGKEVNLQFAIKAKTITSGLKYS 452

  Fly   449 LATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPA 513
            ||||||| |..|...||||||||||||:|||||||||:||||||:|||||||||||:.|||:|||
plant   453 LATGNWG-QANAAGTRAGVSQVLNRLTYASTLSHLRRLNSPIGREGKLAKPRQLHNSQWGMMCPA 516

  Fly   514 ETPEGAAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEIAPSAIADATKIFVNGCWVGIH 578
            |||||.|.|||||||||.||:|||...|||||||||..||.|||:||.|..||||||||.|||:|
plant   517 ETPEGQACGLVKNLALMVYITVGSAAYPILEFLEEWGTENFEEISPSVIPQATKIFVNGMWVGVH 581

  Fly   579 RDPEQLMATLRKLRRQMDIIVSEVSMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEM 643
            |||:.|:.|||:|||::| :.:||.::||||.:|:|||||.||..|||.||:|..||:||..:..
plant   582 RDPDMLVKTLRRLRRRVD-VNTEVGVVRDIRLKELRIYTDYGRCSRPLFIVDNQKLLIKKRDIYA 645

  Fly   644 LKERD-YNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLKQDK---DYAYCTTYTHCEIHPAM 704
            |::|: .....|..|||.|.:|||||.||||.||:|:..||.|.:   :.||...||||||||::
plant   646 LQQRESAEEDGWHHLVAKGFIEYIDTEEEETTMISMTISDLVQARLRPEEAYTENYTHCEIHPSL 710

  Fly   705 ILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYL 769
            ||||||||||||||||||||||||||||||||:|:||:..||||||:|||||.|||||||:||:|
plant   711 ILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGIYVTNYQFRMDTLAYVLYYPQKPLVTTRAMEHL 775

  Fly   770 RFRELPAGINSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEKP 834
            .||:||||||:||||.||:|||||||||:|.|:::||||||:|:|||:|.|.|.....:|:|.:|
plant   776 HFRQLPAGINAIVAISCYSGYNQEDSVIMNQSSIDRGFFRSLFFRSYRDEEKKMGTLVKEDFGRP 840

  Fly   835 HRGTCQGMRNAHYDKLDDDGIIAPGIRVSGDDVVIGKTITLPENDDELDSNTKRFSKRDASTFLR 899
            .||:..|||:..||||||||:..||.||||:||:|||  |.|.:.||....:.|:::||.|..||
plant   841 DRGSTMGMRHGSYDKLDDDGLAPPGTRVSGEDVIIGK--TTPISQDEAQGQSSRYTRRDHSISLR 903

  Fly   900 NSETGIVDQVMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLA 964
            :||||:||||:||.|::|.:|.|:||||||||||||||:||||||||.|:.|.||||.:|.||:.
plant   904 HSETGMVDQVLLTTNADGLRFVKVRVRSVRIPQIGDKFSSRHGQKGTVGMTYTQEDMPWTIEGVT 968

  Fly   965 PDIIINPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPFNDAVNVQKISTFLQEYGYHLRGNEV 1029
            ||||:||||||||||||.||||:.||:.::.|:.||||||.| |.|..||..|.:.||.:||.|.
plant   969 PDIIVNPHAIPSRMTIGQLIECIMGKVAAHMGKEGDATPFTD-VTVDNISKALHKCGYQMRGFER 1032

  Fly  1030 MYNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERD 1094
            ||||||||.:.|.:|||||||||||||||||||||.|||||||.|||.|||:|||||||||||||
plant  1033 MYNGHTGRPLTAMIFLGPTYYQRLKHMVDDKIHSRGRGPVQILTRQPAEGRSRDGGLRFGEMERD 1097

  Fly  1095 CQISHGAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKL 1159
            |.|:||||.||:||||:.||.||||:|..|||||||||:.|:|||:||||||.|.||.:|||.||
plant  1098 CMIAHGAAHFLKERLFDQSDAYRVHVCEVCGLIAIANLKKNSFECRGCKNKTDIVQVYIPYACKL 1162

  Fly  1160 LFQELMSMNIAPRLM 1174
            ||||||||.||||::
plant  1163 LFQELMSMAIAPRML 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	768/1160 (66%)
NRPB2	NP_193902.1	PRK08565	27..1179	CDD:236291	768/1160 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	532	1.000	Domainoid score	I61
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H722
Inparanoid	1	1.050	1509	1.000	Inparanoid score	I11
OMA	1	1.010	-	-		QHG62192
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	1	1.000	-	-		oto2832
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	1	1.100	-	-	LDO	PTHR20856
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840