DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpII140 and NRPD2B

DIOPT Version :9

Sequence 1:	NP_001287323.1	Gene:	RpII140 / 41721	FlyBaseID:	FBgn0262955	Length:	1176	Species:	Drosophila melanogaster
Sequence 2:	NP_188437.2	Gene:	NRPD2B / 821334	AraportID:	AT3G18090	Length:	1055	Species:	Arabidopsis thaliana

Alignment Length:	1120	Identity:	393/1120 - (35%)
Similarity:	581/1120 - (51%)	Gaps:	142/1120 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RLRNLTYSAPLYV--------------DITKTKNVEGLDP--VETQHQKTFIGKIPIMLRSTYCL 163
            ||:|:||||.:.|              |..||...|.::.  ::.:.|...||.||:|::|..|.
plant     4 RLQNMTYSARIKVNAQVEVFKKIVIKHDKFKTGQDEYVEKEILDVKKQDILIGSIPVMVKSVLCK 68

  Fly   164 LSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGKYAFKTEIRSCLEH 228
            .|: ..::..:...|..|.||||:|.|:|||.||||:|.|..::: |......:|::|
plant    69 TSE-KGKENCKKGNCAFDQGGYFVIKGAEKVFIAQEQMCTKRLWI-SNSPWTVSFRSE------- 124

  Fly   229 SSRPTSTLWVNMMARGSQNIKKS--AIGQRIIAILPYIKQEIPIMIVFRALGFVADRDILEHIIY 291
                  |.....:.|.|:|.|..  .|.::::.:. ::..|||:.::|.|||..:|::.::.|.:
plant   125 ------TKRNRFIVRLSENEKAEDYKIMEKVLTVY-FLSTEIPVWLLFFALGVSSDKEAMDLIAF 182

  Fly   292 DFDDPEMMEMVKPSLDEAFVVQEQ----NVALNFIGARGARPGVTKDKRIKYAK--------EIL 344
            |.||..:...:..|:.||..|.|.    |.||.::           :.:||..|        :.|
plant   183 DGDDASITNSLIASIHEADAVCEAFRCGNNALTYV-----------EHQIKSTKFPPAESVDDCL 236

  Fly   345 QKEMLPHV-GVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDLAGPLLAFLFRGL 408
            :..:.|.: |:.     |||.||||||..||.|..|:|:.::||.:.|||::|||.||....|..
plant   237 RLYLFPCLQGLK-----KKARFLGYMVKCLLSAYAGKRKCENRDSFRNKRIELAGELLEREIRVH 296

  Fly   409 FKNLMKEVRMYTQKFIDRGKDFN-LELAIKTNIITDGLRYSLATGNWGDQKKAHQARAGVSQVLN 472
            ..:..:::....||.:....|.. :|..:..::||:||..:.:||.|....:..:..:||...|.
plant   297 LAHARRKMTRAMQKQLSGDGDLKPIEHYLDASVITNGLNRAFSTGAWSHPFRKMERVSGVVANLG 361

  Fly   473 RLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYISVGS 537
            |.....||..|||....:...||:...|..|.:.||.:|...||:|...|||||::|:..:|...
plant   362 RANPLQTLIDLRRTRQQVLYTGKVGDARHPHPSHWGRVCFLSTPDGENCGLVKNMSLLGLVSTQG 426

  Fly   538 QPSPILEFLEEWSMENLEEIAPSAIADATKIFVNGCWVGIHRDPEQLMATLRKLRRQMDIIVSEV 602
            ..| ::|.|....||.|.....:.:....|:.:||.|||:..|.|..:..|:..|||.::.: |:
plant   427 LES-VVEMLFTCGMEELMNDTSTPLCGKHKVLLNGDWVGLCADSESFVGELKSRRRQSELPL-EM 489

  Fly   603 SMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERDYNNYSWQVLVASGVVEYID 667
            .:.||..|.|:||:|||||:.||||:|||         :..||:.....|.::.|:..|::|.|.
plant   490 EIKRDKDDNEVRIFTDAGRLLRPLLVVEN---------LHKLKQDKPTQYPFKHLLDQGILELIG 545

  Fly   668 TLEEETVMIAMSPYD-LKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSAMG 731
            ..|||....|..... ||:.|:      |||||:..:.:|||..:|:||.:|:...|..|||...
plant   546 IEEEEDCTTAWGIKQLLKEPKN------YTHCELDLSFLLGVSCAIVPFANHDHGKRVLYQSQKH 604

  Fly   732 -KQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQEDS 795
             :||:|...||.::|.|||:..|:||.|||..|.:.|.|....|..|.|:|||:..:.|||||||
plant   605 CQQAIGFSSTNPNIRCDTLSQQLFYPQKPLFKTLASECLEKEVLFNGQNAIVAVNVHLGYNQEDS 669

  Fly   796 VILNASAVERGFFRSVFYRSY------KDSENKRVGDQEENFEKPHRGTCQGMRNAHYDKLDDDG 854
            :::|.:::|||.|||...|||      ||||.::..|:...|.|.:      .:....|.|:|||
plant   670 IVMNKASLERGMFRSEQIRSYKAEVDTKDSEKRKKMDELVQFGKTY------SKIGKVDSLEDDG 728

  Fly   855 IIAPGIRVSGDDVVIGKTITLPENDDELDSNTKRFSKRDASTFLRNSETGIVDQVMLTLNSEGYK 919
            ....|..:|..|:|||:...               |..|.|..|:::|.|||.:|:|:.|.||..
plant   729 FPFIGANMSTGDIVIGRCTE---------------SGADHSIKLKHTERGIVQKVVLSSNDEGKN 778

  Fly   920 FCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIIINPHAIPSRMTIGHLI 984
            |..:.:|.||.|.:||||:|.|||||..|....|::..||.:|:.|||:|||||.|||.|.|.|:
plant   779 FAAVSLRQVRSPCLGDKFSSMHGQKGVLGYLEEQQNFPFTIQGIVPDIVINPHAFPSRQTPGQLL 843

  Fly   985 EC---------LQGKLGSNKGE---IGDATPFNDAVNVQKISTFLQEYGYHLRGNEVMYNGHTGR 1037
            |.         :|.|.||:...   ...||||: ...|.:|:..|...|:...|||.:|||.:|.
plant   844 EAALSKGIACPIQKKEGSSAAYTKLTRHATPFS-TPGVTEITEQLHRAGFSRWGNERVYNGRSGE 907

  Fly  1038 KINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISHGAA 1102
            .:.:.:|:|||:||||.||.::|:..|..|||..|.|||:..|.|.||:|||||||||.|:|||:
plant   908 MMRSLIFMGPTFYQRLVHMSENKVKFRNTGPVHPLTRQPVADRKRFGGIRFGEMERDCLIAHGAS 972

  Fly  1103 QFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFE-------------CKGCKNKTQISQVRLP 1154
            ..|.||||.:||..::|||..|...|      |..|             |:.|.:...:.:|.:|
plant   973 ANLHERLFTLSDSSQMHICRKCKTYA------NVIERTPSSGRKIRGPYCRVCASSDHVVRVYVP 1031

  Fly  1155 YAAKLLFQELMSMNI 1169
            |.||||.|||.||.|
plant  1032 YGAKLLCQELFSMGI 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	393/1120 (35%)
NRPD2B	NP_188437.2	PRK08565	1..1046	CDD:236291	392/1118 (35%)
		RNA_pol_B_RPB2	3..1051	CDD:238353	393/1120 (35%)
		RNA_pol_Rpb2_4	456..517	CDD:282431	27/61 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	1	1.100	-	-	O	PTHR20856
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780