Protein Alignment Polr2B and Polr3b

DIOPT Version :10

• Sequence 1: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: NP_081699.1
• Gene: Polr3b / 70428
• MGIID: 1917678
• Length: 1133
• Species: Mus musculus
• Alignment Length: 1179
• Identity: 453/1179 - (38%)
• Similarity: 681/1179 - (57%)
• Gaps: 106/1179 - (8%)

  Fly    25 EACWIVINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKF 89
            |..|.::.|:...||||:|.:|||:.||.:.:::|::.:..:...|:           |.:.||:
Mouse    24 EEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDAD-----------PMWYLKY 77

  Fly    90 EQIYLSKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVDITKTKN----VEGLDPVETQHQKTFI 150
            ..||:..|...|......|:.|:|.|||::|||||:.|||..|:.    :....|         |
Mouse    78 LNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALP---------I 133

  Fly   151 GKIPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGK 215
            |::||||||:.|:|:..|..:..:|||||||||||||:.|.|||::.||:::.|.:.|.:  |.|
Mouse   134 GRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRK 196

  Fly   216 YAFKTEIRSCL-EHSSRPTSTLWVNM-MARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALG 278
            .|....:.|.. |..||      .|| :.:|...::.:.           :.::|||:|:|:|:|
Mouse   197 GAVGASVTSSTHEKKSR------TNMAVKQGRFYLRHNT-----------LSEDIPIVIIFKAMG 244

  Fly   279 FVADRDIL------EHIIYDFDDPEMMEMVKPSLDEAFVVQ--EQNVALNFIGARGARP----GV 331
            ..:|::|:      ||::..|.         |||:|....|  .|..||.:||.:..|.    |.
Mouse   245 VESDQEIVQMIGTEEHVMAAFG---------PSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG 300

  Fly   332 TKDKRIKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDL 396
            .|..:|:.|:|:|...:|.||.|.:|....|..:...||.|::||. |..::||||:||||||:|
Mouse   301 PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLEL 364

  Fly   397 AGPLLAFLFRGLFKNLMKEVRMYTQKFI--DRGKDFNLELAIKTNIITDGLRYSLATGNWGDQKK 459
            ||.||:.||..|||....|::....:.|  .|...|::...::.:.||:|:..:::|||| ..|:
Mouse   365 AGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW-SLKR 428

  Fly   460 AHQARAGVSQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLV 524
            ....|.||:|||:||::.|.|..:.|::|...:..|::.||.|..:.||||||::||||.|.|||
Mouse   429 FKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLV 493

  Fly   525 KNLALMAYISVGSQPSPILEFLEEWSMENL-----EEIA-PSAIADATKIFVNGCWVGIHRDPEQ 583
            ||||||.:|:...:..||::......:|::     ||:: |:...    :|:||..:|:.||.::
Mouse   494 KNLALMTHITTDMEDGPIIKLAGNLGVEDVNLLCGEELSYPNVFL----VFLNGNILGVIRDHKK 554

  Fly   584 LMATLRKLRRQMDIIVSEVSMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERD 648
            |::|.|.:|| ...|...||:..::.||.:.|.:|.||:|||.:||:.....:...|:|.|.: .
Mouse   555 LVSTFRLMRR-AGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQ-G 617

  Fly   649 YNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASII 713
            |.|:  :..:...:|||:|..||....||:..:.:.:|.        ||.||.|..:|||||.:|
Mouse   618 YRNF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT--------THLEIEPFTLLGVCAGLI 672

  Fly   714 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGI 778
            |:|.||||||||||.||||||||....|...|:|||.::|.||.||:|.|:::|.:.|.:||||.
Mouse   673 PYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIDFEKLPAGQ 737

  Fly   779 NSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEK---PHRGTCQ 840
            |:.||::.|:||:.||:::||.::::|||.|.:.|::.| ...||..:|  .|:|   |......
Mouse   738 NATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAK-CTLKRYTNQ--TFDKVMGPMLDAAT 799

  Fly   841 GMRNAHYDKLDDDGIIAPGIRVSGDDVVIGKTI-TLPENDDELDSNTKRFSKRDASTFLRNSETG 904
            ......::.||.|||.:||.:|....|::.|:: |:.:...|..:..::...:|.....:.:...
Mouse   800 RKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDS 864

  Fly   905 IVDQVMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIII 969
            .:::||::.|:|.....|:.:|..|.|:|||||:|||||||.||:...||||.|...|:.||||:
Mouse   865 YIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIM 929

  Fly   970 NPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPFNDAVNVQKISTFLQEYGYHLRGNEVMYNGH 1034
            |||..|||||:|.|||.|.||.|...|.....|.|..: .|:.:...|..:||:..|.:.:.:|.
Mouse   930 NPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGS-KVKDVCEDLVRHGYNYLGKDYVTSGI 993

  Fly  1035 TGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISH 1099
            ||..:.|.::.||.|||:|||||.||:|:|||||..:|.|||.|||:||||||.|||||||.|.:
Mouse   994 TGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGY 1058

  Fly  1100 GAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQEL 1164
            ||:..|.|||...||.:.|.:|..|||:..:..      |..||:...:|.:|:|||.|||||||
Mouse  1059 GASMLLLERLMISSDAFEVDVCGQCGLLGYSGW------CHYCKSSCHVSSLRIPYACKLLFQEL 1117

  Fly  1165 MSMNIAPRL 1173
            .||||.|||
Mouse  1118 QSMNIIPRL 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	452/1176 (38%)
Polr3b	NP_081699.1	RNA_pol_B_RPB2	39..1127	CDD:238353	448/1164 (38%)
		RNA_pol_Rpb2_4	539..600	CDD:428012	24/61 (39%)
		RNA_pol_Rpb2_5	621..661	CDD:428013	13/49 (27%)