Protein Alignment RpII140 and POLR3B

DIOPT Version :9

• Sequence 1: NP_001287323.1
• Gene: RpII140 / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: NP_060552.4
• Gene: POLR3B / 55703
• HGNCID: 30348
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 1182
• Identity: 453/1182 - (38%)
• Similarity: 682/1182 - (57%)
• Gaps: 106/1182 - (8%)

  Fly    25 EACWIVINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKF 89
            |..|.::.|:...||||:|.:|||:.||.:.:::|::.:..:...|:           |.:.||:
Human    24 EEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMKANEKVTSDAD-----------PMWYLKY 77

  Fly    90 EQIYLSKPTHWEKDGSPSPMMPNEARLRNLTYSAPLYVDITKTKN----VEGLDPVETQHQKTFI 150
            ..||:..|...|......|:.|:|.|||::|||||:.|||..|:.    :....|         |
Human    78 LNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYTRGSQRIIRNALP---------I 133

  Fly   151 GKIPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDGK 215
            |::||||||:.|:|:..|..:..:|||||||||||||:.|.|||::.||:::.|.:.|.:  |.|
Human   134 GRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILIQEQLSKNRIIVEA--DRK 196

  Fly   216 YAFKTEIRSCL-EHSSRPTSTLWVNM-MARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALG 278
            .|....:.|.. |..||      .|| :.:|...::.:.           :.::|||:|:|:|:|
Human   197 GAVGASVTSSTHEKKSR------TNMAVKQGRFYLRHNT-----------LSEDIPIVIIFKAMG 244

  Fly   279 FVADRDIL------EHIIYDFDDPEMMEMVKPSLDEAFVVQ--EQNVALNFIGARGARP----GV 331
            ..:|::|:      ||::..|.         |||:|....|  .|..||.:||.:..|.    |.
Human   245 VESDQEIVQMIGTEEHVMAAFG---------PSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG 300

  Fly   332 TKDKRIKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKRLDL 396
            .|..:|:.|:|:|...:|.||.|.:|....|..:...||.|::||. |..::||||:||||||:|
Human   301 PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQ-GDNKVDDRDYYGNKRLEL 364

  Fly   397 AGPLLAFLFRGLFKNLMKEVRMYTQKFI--DRGKDFNLELAIKTNIITDGLRYSLATGNWGDQKK 459
            ||.||:.||..|||....|::....:.|  .|...|::...::.:.||:|:..:::|||| ..|:
Human   365 AGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAISTGNW-SLKR 428

  Fly   460 AHQARAGVSQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAVGLV 524
            ....|.||:|||:||::.|.|..:.|::|...:..|::.||.|..:.||||||::||||.|.|||
Human   429 FKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLV 493

  Fly   525 KNLALMAYISVGSQPSPILEFLEEWSMENL-----EEIA-PSAIADATKIFVNGCWVGIHRDPEQ 583
            ||||||.:|:...:..||::......:|::     ||:: |:...    :|:||..:|:.||.::
Human   494 KNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFL----VFLNGNILGVIRDHKK 554

  Fly   584 LMATLRKLRRQMDIIVSEVSMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERD 648
            |:.|.|.:|| ...|...||:..::.||.:.|.:|.||:|||.:||:.....:...|:|.|.: .
Human   555 LVNTFRLMRR-AGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVKKQKPAVTNKHMEELAQ-G 617

  Fly   649 YNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASII 713
            |.|:  :..:...:|||:|..||....||:..:.:.:|.        ||.||.|..:|||||.:|
Human   618 YRNF--EDFLHESLVEYLDVNEENDCNIALYEHTINKDT--------THLEIEPFTLLGVCAGLI 672

  Fly   714 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGI 778
            |:|.||||||||||.||||||||....|...|:|||.::|.||.||:|.|:::|.:.|.:||||.
Human   673 PYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMVKTKTIELIEFEKLPAGQ 737

  Fly   779 NSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENFEK---PHRGTCQ 840
            |:.||::.|:||:.||:::||.::::|||.|.:.|::.| ...||..:|  .|:|   |......
Human   738 NATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAK-CTLKRYTNQ--TFDKVMGPMLDAAT 799

  Fly   841 GMRNAHYDKLDDDGIIAPGIRVSGDDVVIGKTI-TLPENDDELDSNTKRFSKRDASTFLRNSETG 904
            ......::.||.|||.:||.:|....|::.|:: |:.:...|..:..::...:|.....:.:...
Human   800 RKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPLEGSNVPQQPQYKDVPITYKGATDS 864

  Fly   905 IVDQVMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDIII 969
            .:::||::.|:|.....|:.:|..|.|:|||||:|||||||.||:...||||.|...|:.||||:
Human   865 YIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSRHGQKGVCGLIVPQEDMPFCDSGICPDIIM 929

  Fly   970 NPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPFNDAVNVQKISTFLQEYGYHLRGNEVMYNGH 1034
            |||..|||||:|.|||.|.||.|...|.....|.|..: .|:.:...|..:||:..|.:.:.:|.
Human   930 NPHGFPSRMTVGKLIELLAGKAGVLDGRFHYGTAFGGS-KVKDVCEDLVRHGYNYLGKDYVTSGI 993

  Fly  1035 TGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDCQISH 1099
            ||..:.|.::.||.|||:|||||.||:|:|||||..:|.|||.|||:||||||.|||||||.|.:
Human   994 TGEPLEAYIYFGPVYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGY 1058

  Fly  1100 GAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFECKGCKNKTQISQVRLPYAAKLLFQEL 1164
            ||:..|.|||...||.:.|.:|..|||:..:..      |..||:...:|.:|:|||.|||||||
Human  1059 GASMLLLERLMISSDAFEVDVCGQCGLLGYSGW------CHYCKSSCHVSSLRIPYACKLLFQEL 1117

  Fly  1165 MSMNIAPRLMVT 1176
            .||||.|||.::
Human  1118 QSMNIIPRLKLS 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpII140	NP_001287323.1	PRK08565	28..1176	CDD:236291	452/1177 (38%)
POLR3B	NP_060552.4	RNA_pol_B_RPB2	39..1127	CDD:238353	447/1163 (38%)
		RNA_pol_Rpb2_4	539..600	CDD:398322	24/61 (39%)
		RNA_pol_Rpb2_5	621..661	CDD:398323	13/49 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0085
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42570at2759
OrthoFinder	1	1.000	-	-		FOG0000346
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100190
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X610
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720