Protein Alignment Polr2B and rpc-2

DIOPT Version :10

• Sequence 1: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: NP_498192.2
• Gene: rpc-2 / 175767
• WormBaseID: WBGene00017300
• Length: 1154
• Species: Caenorhabditis elegans
• Alignment Length: 1196
• Identity: 435/1196 - (36%)
• Similarity: 675/1196 - (56%)
• Gaps: 127/1196 - (10%)

  Fly    28 WIVINAYFDEKGLVRQQLDSFDEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKFEQI 92
            |:::.|:...:|||:|.|.|||.|:|..::.|:..:..|...|.           |.|.||:..|
 Worm    29 WLLVPAFLKVRGLVKQHLVSFDHFVQEEIRSIMLSNQKITSDAN-----------PNFYLKYLDI 82

  Fly    93 YLSKPTHWEKDG---SPSPMMPNEARLRNLTYSAPLYVDITKTKNVEGLDPVETQHQKTF----- 149
            .:.||:  .::|   :...:.|.|.|||::|||||:.|||..|:.          :|:.|
 Worm    83 RIGKPS--SEEGLNMTHDKITPQECRLRDMTYSAPISVDIEYTRG----------NQRVFKKDLI 135

  Fly   150 IGKIPIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFSMKDG 214
            ||::||||||:.|:|..|.:.:|..:.|||.||||||::.|||||::.||:::.|.:.|     |
 Worm   136 IGRMPIMLRSSKCILRDLAEEELARVQECPYDPGGYFVVKGSEKVILIQEQLSKNRIMV-----G 195

  Fly   215 KYAFKTEIRSCLEHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPYIKQEIPIMIVFRALGF 279
            :.:.|......|..:|...|..:|. |.:|..:::.:           .:..::|:.|:|:|:|.
 Worm   196 RNSSKELQCEVLSSTSERKSKTYVT-MKKGKYSVRHN-----------QLTDDVPVSIIFKAMGV 248

  Fly   280 VADRDILEHIIYDFDDPEMMEMVKPSLDEAF--VVQEQNVALNFIGAR---------GARPG--- 330
            .:|.||:..|.:   :.:.:.....:|:|:.  .|..|..||.::.::         |:.||
 Worm   249 ESDFDIVSTIGH---EEKYVSAFAQTLEESINAGVYTQQQALAYVTSKVKARKFTPFGSLPGTSV 310

  Fly   331 --VTKDKRIKYAKEILQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLASLGRRELDDRDHYGNKR 393
              :|..|..: |.:.|...|:.|:...|.....||.:||.|..||:...||...|||||.|||||
 Worm   311 SVLTPPKEHE-AVDFLSNSMITHIACPDGNFKMKAIYLGLMTRRLIQTELGENGLDDRDFYGNKR 374

  Fly   394 LDLAGPLLAFLFRGLFKNLMKEVRMYTQKFIDRGKDFNLELA--IKTNIITDGLRYSLATGNWGD 456
            |:|||.||:.||..:||....|::......:.:.....|::.  ::.::||:.:..:::|||| .
 Worm   375 LELAGSLLSLLFEDVFKRFNSELKRIADNALMKTMAAPLDIVKHMRQDMITNTIVNAMSTGNW-I 438

  Fly   457 QKKAHQARAGVSQVLNRLTFASTLSHLRRVNSPIGRDGKLAKPRQLHNTLWGMLCPAETPEGAAV 521
            .|:....|.||:|||:||::.|.|..:.|:||...:..|::.||.|..:.||||||::||||.|.
 Worm   439 IKRFRMERLGVTQVLSRLSYISALGMMTRINSTFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEAC 503

  Fly   522 GLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEIAPSAI--ADATKIFVNGCWVGIHRDPEQL 584
            ||||||||:::|:..|...|:|..|....:|:|..:..|.:  .:.|.||:||..:|...|||::
 Worm   504 GLVKNLALISHITTDSDEKPVLRLLLNSGVEDLHNVHFSHVNKPENTLIFLNGVLIGTAVDPERV 568

  Fly   585 MATLRKLRRQMDIIVSE-VSMIRDIRDREIRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERD 648
            :..:|.|||..  ::|| ||:.|.:.:|.:.|.:|.||:|||.:||:||:.:|.:.||:.|||
 Worm   569 VKAVRDLRRSG--LLSEFVSVSRSLTNRSVFISSDGGRLCRPYIIVKNGTPMLTQAHVQELKE-- 629

  Fly   649 YNNYSWQVLVASGVVEYIDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASII 713
             ....::..|..|:|||:|..|....:||:...::..:.        ||.||.|..:|||||.:|
 Worm   630 -GKMIFEDFVDDGIVEYLDVNEMNDALIAVYGREIGPET--------THLEIEPFTLLGVCAGLI 685

  Fly   714 PFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGI 778
            |:|.||||||||||.||||||||....|...|:|::.::|.||.:|||.::::|...|.:||||.
 Worm   686 PYPHHNQSPRNTYQCAMGKQAMGTIAYNQQKRIDSIMYLLCYPQRPLVKSKTIELTNFEKLPAGA 750

  Fly   779 NSIVAILCYTGYNQEDSVILNASAVERGFFRSVFYRSYKDSENK---RVGDQ------EENFEKP 834
            |.|:|::.|:||:.||:::||.::::||:.|.:.|:..|.:..|   :..|:      :.|..||
 Worm   751 NGIIAVMSYSGYDIEDALVLNKASLDRGYGRCLVYKHVKGTAKKYPNQTFDRLLGPALDPNTRKP 815

  Fly   835 ---HRGTCQGMRNAHYDKLDDDGIIAPGIRVSGDDVVIGKTITLPENDD----ELDSNT-----K 887
               |:            .||.:||:..|.|:.....:|.|.:.:...:.    ...:||     :
 Worm   816 IFKHK------------NLDQEGIVFAGARIMPKQTIINKHMPVVSGESGPGASASANTIGIAGR 868

  Fly   888 RFSKRDASTFLRNSETGIVDQVMLTLNSEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYR 952
            :...:|.|...:.......::|:||.|.:.....|:.:|..|.|::||||:|||||||.||:..:
 Worm   869 QVDYKDVSITYKTPTPSYAERVLLTYNEDEAHLFKVLLRQTRRPELGDKFSSRHGQKGVCGLIAQ 933

  Fly   953 QEDMAFTCEGLAPDIIINPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPFNDAVNVQKISTFL 1017
            ||||.|...|:.||:|:|||..|||||:|.|:|.|.||.|...|.....|.|. ...|:.:...|
 Worm   934 QEDMPFNDLGMVPDMIMNPHGYPSRMTVGKLMELLSGKAGVVNGTYHYGTAFG-GDQVKDVCEEL 997

  Fly  1018 QEYGYHLRGNEVMYNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRAR 1082
            ...||:..|.:::.:|.||:.::|.::.||.|||:|||||.||:|:|||||...|.|||.|||:|
 Worm   998 AACGYNYMGKDMLTSGITGQPLSAYIYFGPIYYQKLKHMVLDKMHARARGPRAALTRQPTEGRSR 1062

  Fly  1083 DGGLRFGEMERDCQISHGAAQFLRERLFEVSDPYRVHICNFCGLIAIANLRNNTFECKGCKNKTQ 1147
            :||||.|||||||.|::||:..|.|||...||.::|.:|..||:|.....      |:.|::...
 Worm  1063 EGGLRLGEMERDCLIAYGASMLLIERLMVSSDEFKVDVCTGCGVIGSKGW------CQKCRSSKS 1121

  Fly  1148 ISQVRLPYAAKLLFQELMSMNIAPRL 1173
            ::.:::|||.|||||||.||||.|||
 Worm  1122 MANIKIPYACKLLFQELQSMNIVPRL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	435/1196 (36%)
rpc-2	NP_498192.2	RNA_pol_B_RPB2	41..1148	CDD:238353	432/1184 (36%)
		RNA_pol_Rpb2_4	552..613	CDD:428012	26/62 (42%)
		RNA_pol_Rpb2_5	634..674	CDD:428013	13/47 (28%)